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CUCURBITACIN B

CUCURBITACIN B Structure
CUCURBITACIN B
  • CAS No.6199-67-3
  • Chemical Name:CUCURBITACIN B
  • CBNumber:CB5113260
  • Molecular Formula:C32H46O8
  • Formula Weight:558.7
  • MOL File:6199-67-3.mol
CUCURBITACIN B Property
  • Melting point 184-186°
  • alpha D25 +88° (c = 1.55 in ethanol)
  • Boiling point 546.74°C (rough estimate)
  • Density 1.0953 (rough estimate)
  • refractive index 1.4900 (estimate)
  • storage temp. Keep in dark place,Sealed in dry,2-8°C
  • solubility DMSO: soluble10mg/mL, clear
  • form powder
  • pka 12.60±0.29(Predicted)
  • color white to beige
  • λmax 290nm(EtOH)(lit.)
  • Merck 14,2614
  • Stability Hygroscopic
  • InChIKey IXQKXEUSCPEQRD-ALLWXVAWSA-N
  • FDA UNII 0115W5MABF
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
  • Hazard Codes  :T
  • Risk Statements  :25
  • Safety Statements  :45-24/25
  • RIDADR  :UN 2811 6.1 / PGI
  • WGK Germany  :3
  • RTECS  :RC6190000
  • HazardClass  :6.1
  • PackingGroup  :II
  • HS Code  :29153900
  • Hazardous Substances Data :6199-67-3(Hazardous Substances Data)
  • Toxicity :LD10 orally in mice: 5 mg/kg (LeMen)
  • NFPA 704:
    0
    3 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300
  • Precautionary statements P264-P270-P301+P310-P405-P501
CUCURBITACIN B Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: C8499
  • Product name : Cucurbitacin B hydrate
  • Purity: ≥97% (HPLC)
  • Packaging: 5MG
  • Price: ₹26542.9
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C8499
  • Product name : Cucurbitacin B hydrate
  • Purity: ≥97% (HPLC)
  • Packaging: 25MG
  • Price: ₹103292.15
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: C3442
  • Product name : Cucurbitacin B
  • Purity: 
  • Packaging: 5MG
  • Price: ₹7100
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: C3442
  • Product name : Cucurbitacin B
  • Purity: 
  • Packaging: 25MG
  • Price: ₹17800
  • Updated: 2022/05/26
  • Buy: Buy

CUCURBITACIN B Chemical Properties,Usage,Production

  • Description Cucurbitacin B is a tetracyclic triterpenoid that has been shown to have a strong antitumor activity.
  • Chemical Properties White solid
  • Uses Cucurbitacin B hydrate has been used:
    • as a signal transducer and activator of transcription 3 (stat3) inhibitor to determine its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs).
    • as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydoxyecdysone (20E) signaling in butterflies.
    • to determine its effect on the cell viability of pancreatic cancer cell lines.

  • Definition ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.
  • Biochem/physiol Actions Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I.
CUCURBITACIN B Preparation Products And Raw materials
Raw materials
Preparation Products
CUCURBITACIN B Suppliers
Global(281)Suppliers
  • Supplier：
    Henan Fengda Chemical Co., Ltd
  • Tel：+86-371-86557731<br/>+86-13613820652
  • Email：info@fdachem.com
  • Country：China
  • ProdList：20234
  • Advantage：58
CUCURBITACIN B Spectrum
6199-67-3, CUCURBITACIN BRelated Search:
  • standardized herbal extract
  • reference standards from Chinese medicinal herbs (TCM).
  • phytochemical
  • pharmaceutical intermediate
  • chemical reagent
  • Tri-Terpenoids
  • 中药标准品，对照品
  • 抑制剂
  • 天然产物
  • 化学试剂
  • 苦味素
  • 分析试剂标准品
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  • 标准品，对照品
  • 化工原料
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  • 对照品,标准品
  • 植提标准品
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  • 中药对照品
  • 中草药成分
  • C32H46O8
  • 葫芦素 B,10 MM DMSO 溶液
  • 葫芦素B 水合物
  • (R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-二羟基-4,4,9,13,14-五甲基-3,11-二氧代-2,3,4,7,8,9,10,11,12,13,14,15,16,17-十四氢-1H-环戊烷[A]菲-17-基)-6-羟基-2-甲基-5-氧代庚-3-烯-2-基 乙酸酯
  • 葫芦素B(对照品)
  • 葫芦素 B, >99%
  • 葫芦素BCUCURBITACIN B
  • 葫芦素B(甄准不供应)
  • 双氢葫芦素F-25-乙酸酯
  • 葫芦素B
  • 双氢葫芦苦素F-25-乙酸酯
  • 葫芦苦素B
  • 雪胆甲素
  • 葫芦素B(标准品)
  • 葫芦苦素B,双氢葫芦苦素F-25-乙酸酯
  • 葫芦素B, 来源于甜瓜蒂
  • CUCURBITACIN B 葫芦素B
  • 葫芦素B(葫芦苦素B,双氢葫芦苦素F-25-乙酸酯)
  • 葫芦素B(葫芦苦素B)
  • 6199-67-3
  • Cucurbitacin B, 10 mM in DMSO
  • Cucurbitacin B-RM
  • 1,2-Dihydro-a-elaterin
  • (R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate
  • (+)-Cucurbitacin B
  • cucuritacin B
  • CAS?6199-67-3?Combretastatin A4 (Z) -Combretastatin A4 CAS 117048-59-6
  • CUCURBITACIN B USP/EP/BP
  • 19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2β,9β,10α,16α,23E)-

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