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Cucurbitacin E

Cucurbitacin E Structure
Cucurbitacin E
  • CAS No.18444-66-1
  • Chemical Name:Cucurbitacin E
  • CBNumber:CB3372306
  • Molecular Formula:C32H44O8
  • Formula Weight:556.69
  • MOL File:18444-66-1.mol
Cucurbitacin E Property
  • Melting point 228-234°C
  • alpha D -59° (c = 0.7 in chloroform)
  • Boiling point 545.56°C (rough estimate)
  • Density 1.1059 (rough estimate)
  • refractive index 1.4900 (estimate)
  • storage temp. -20°C
  • solubility DMSO: soluble15mg/mL, clear
  • form powder
  • pka 8.51±0.70(Predicted)
  • color white to beige
  • optical activity [α]/D -60 to -75°, c = 0.7 (CDCl3)
  • InChIKey NDYMQXYDSVBNLL-MUYMLXPFSA-N
  • LogP 3.150 (est)
  • FDA UNII V8A45XYI21
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :25-22
  • Safety Statements  :1-22-45-24/25
  • RIDADR  :3172
  • WGK Germany  :3
  • RTECS  :RC6305500
  • HS Code  :29153900
  • Toxicity :LD50 orally in mice: 340 mg/kg (Albert)
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P301+P312+P330
Cucurbitacin E Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0577
  • Product name : Cucurbitacin E
  • Purity: ≥95% (HPLC)
  • Packaging: 5MG
  • Price: ₹24745.95
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0577
  • Product name : Cucurbitacin E
  • Purity: ≥95% (HPLC)
  • Packaging: 25MG
  • Price: ₹99395.15
  • Updated: 2022/06/14
  • Buy: Buy

Cucurbitacin E Chemical Properties,Usage,Production

  • Description Cucurbitacin E is a plant-derived triterpene that has diverse biological activities. At a concentration of 10 pM, it reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro. Cucurbitacin E inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC50s = 50-1,000 nM) through induction of G2/M arrest and apoptosis. It increases bilirubin binding to human serum albumin (HSA) in human plasma in a dose-dependent manner. Cucurbitacin E also inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells.
  • Chemical Properties white to beige powder
  • Uses Cucurbitacin E has been used as a cofilin inhibitor. It is also used as a F-actin stabilizer to prevent membrane-associated periodic skeleton (MPS) loss and protect from axonal fragmentation.
  • Uses Cucurbitacin E is a biochemical compound from the family of Cucurbitacins. Cucurbitacin E is a highly oxidated steroid consisting of a tetracyclic triterpene. Cucurbitacin E is known to possess broad spectrum of potential anti-inflammatory, antitumor andantioxidant effects.
  • Definition ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23.
  • General Description This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG.
  • Biochem/physiol Actions Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation.
Cucurbitacin E Preparation Products And Raw materials
Raw materials
Preparation Products
Cucurbitacin E Suppliers
Global(218)Suppliers
  • Supplier：
    career henan chemical co
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  • Email：sales@coreychem.com
  • Country：China
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  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
Cucurbitacin E Spectrum
18444-66-1, Cucurbitacin ERelated Search:
  • phytochemical
  • pharmaceutical intermediate
  • chemical reagent
  • Tri-Terpenoids
  • standardized herbal extract
  • reference standards from Chinese medicinal herbs (TCM).
  • 中药标准品，对照品
  • 化学试剂
  • 抑制剂
  • 试剂
  • 药靶配体
  • 化合物
  • 苦味素
  • 标准品，对照品
  • 标准品 -中药标准品
  • 三萜
  • 标准品-中药标准品
  • 标准品-对照品
  • 分析试剂标准品
  • 分析对照品
  • 植提标准品
  • 对照品
  • 植物提取物
  • 标准品
  • 中药对照品
  • 中草药成分
  • C32H44O8
  • 葫芦素 E,10 MM DMSO 溶液
  • (R,E)-6-((8S,9R,10R,13R,14S,16R,17R)-2,16-二羟基-4,4,9,13,14-五甲基-3,11-二氧代-4,7,8,9,10,11,12,13,15,16,17-十二氢-3H-环戊基[A]菲-17-基)-6-羟基-2-甲基-5-氧代庚-3-烯-2-基 乙酸酯
  • 葫芦素E对照品
  • 葫芦素 E, 来源于甜瓜
  • 葫芦素 E, >99%
  • 葫芦素E(标准品)
  • 葫芦素E(葫芦苦素E)
  • 葫芦苦素E
  • 葫芦素 E
  • 18444-66-1
  • Cucurbitacin E, 10 mM in DMSO
  • Cucurbitacin E-RM
  • Cucurbitacin E(P)
  • Cucurbitine E
  • (R,E)-6-((8S,9R,10R,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-4,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate
  • 2,16α,20,25-tetrahydroxy-9β-methyl-10α,-19-norlanosta-1,5...
  • Cucurbitacin E USP/EP/BP
  • 19-Norlanosta-1,5,23-triene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (9β,10α,16α,23E)-
  • 2,16α,20,25-tetrahydroxy-9β-methyl-10α,-19-norlanosta-1,5,23(E)-triene-3,11,22-trione 25-acetate
  • Cucurbitacin E (α-Elaterin
  • Cucurbitacin E, >99%
  • Cucurbitacin E 18444-66-1
  • Cucurbit E
  • Cucurbitacin E, 98%, from Cucumis melo L.
  • α-Elaterine
  • (9β,10α,23E)-25-Acetyloxy-2,16α,20-trihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
  • (9β,10α,23E)-25-(Acetyloxy)-2,16α,20-trihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
  • CUCURBITACIN E hplc
  • (10α,23E)-25-(Acetyloxy)-2,16α,20-trihydroxy-9β-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
  • [(E,6R)-6-[(8S,9R,10R,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate
  • CUCURBITACIN E WITH HPLC

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