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AROTINOLOL

AROTINOLOL Structure
AROTINOLOL
  • CAS No.68377-92-4
  • Chemical Name:AROTINOLOL
  • CBNumber:CB4486237
  • Molecular Formula:C15H21N3O2S3
  • Formula Weight:371.54
  • MOL File:68377-92-4.mol
AROTINOLOL Property
  • Melting point 148-149°
  • Boiling point 599.8±60.0 °C(Predicted)
  • Density 1.35
  • storage temp. 2-8°C(protect from light)
  • solubility DMSO (Slightly), Methanol (Slightly)
  • pka 13.71±0.20(Predicted)
  • form Solid
  • color Off-White to Pale Yellow
  • FDA UNII 394E3P3B99
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

AROTINOLOL Chemical Properties,Usage,Production

  • Originator Arotinolol,ZYF Pharm
  • Uses Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.
  • Definition ChEBI: Arotinolol is a member of thiophenes and an aromatic amide.
  • Manufacturing Process To a solution of 2-mercapto-4-(5'-carbamoyl-2'-thiophenyl)thiazole, 3.2 g in 20 ml of 0.3 % aqueous sodium hydroxide solution, 1-chloro-3-tbutylaminopropanol, 12.64 g in 20 ml of methanol was added, while the temperature was maintained at 20°C.
    The reaction solution was stirred at room temperature for 4 h, and then condensed to a half volume in vacuo. The residual solution, added with 100 ml of water, was extracted with chloroform. The chloroform extract was washed with water, dried over anhydrous magnesium sulfate and evaporated in vacuo to give 4.8 g of 2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'- thiophenyl)thiazole, as crystals, melting point 234°-235.5°C (dec., recrystallized from methanol/water).
    In practice it is usually used as hydrochloride.
  • Therapeutic Function Beta-adrenergic blocker
AROTINOLOL Preparation Products And Raw materials
Raw materials
Preparation Products
AROTINOLOL Suppliers
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AROTINOLOL Spectrum
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  • 5-(2-{[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl}-1,3-thiazol-4-yl)-2-thiophenecarboxamide
  • Arolol
  • Arot-API
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  • AROTINOLOL USP/EP/BP
  • Arotinolol free base
  • Arotinolol Solution, 100ppm
  • Arotinolol Solution, 1000ppm
  • Arotinolo
  • 5-(2-((3-(tert-Butylamino)
  • 5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide
  • 5-[2-[3-(tert-butylamino)-2-hydroxy-propyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide
  • 5-[2-[[3-(tert-butylamino)-2-hydroxy-propyl]thio]thiazol-4-yl]thiophene-2-carboxamide
  • NSC 317940
  • 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, (+-)-
  • 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-
  • 2-(3-tert-Butylamino-2-hydroxypropylthio)-4-(5-carbamoyl-2-thienyl)thiazole
  • Arottnolol
  • AROTINOLOL

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