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Lercanidipine

Lercanidipine Structure
Lercanidipine
  • CAS No.100427-26-7
  • Chemical Name:Lercanidipine
  • CBNumber:CB4133658
  • Molecular Formula:C36H41N3O6
  • Formula Weight:611.73
  • MOL File:100427-26-7.mol
Lercanidipine Property
  • Melting point 118-120°C
  • Boiling point 712.5±60.0 °C(Predicted)
  • Density 1.177±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility Soluble in DMSO
  • form Powder
  • pka 8.66±0.50(Predicted)
  • color Light yellow to yellow
  • CAS DataBase Reference 100427-26-7(CAS DataBase Reference)
  • FDA UNII V7XTJ4R0BH
  • ATC code C08CA13
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H302-H360
  • Precautionary statements P201-P308+P313

Lercanidipine Chemical Properties,Usage,Production

  • Description Lerdip was launched in the Netherlands for hypertension. It is prepared in four steps, the last of which is a Hantsch reaction of 1-[(3,3-diphenyl)-N-methylpropylamino]- 2-methyl-2-propyl-2-(3-nitrobenzylidene)acetoacetate with methyl 3-aminocrotonate. This compound was designed to be very lipophilic which imparts the drug with a gradual onset and a long duration of action as a result of prolonged exposure to receptors by partitioning into membranes. It is an antagonist of L-type calcium channels with no activity in smooth muscle cells, is tissue selective, lacks any myocardial contractility impairment, has no neuroendocrine activation, and has negligible affinity for neurotransmitter receptors such as α1- and α2-adrenergic receptors. While sold as a racemate, the calcium channel activity is found in the (S)- isomer with the (R)-isomer being 2-orders of magnitude less active. It has an increased cardiac contractility index which is much more than Nitrendipine or nifedipine. The good selectivity causes a reduction in blood pressure with no negative inotropic effects.
  • Originator Recordati (Italy)
  • Uses Antihypertensive compound; calcium channel blocker.
  • Definition ChEBI: Lercanidipine is a diarylmethane.
  • brand name Cardiovasc (Recor dati, Italy); Carmen (Recordati, Italy); Corifeo (Recordati, Italy); Lercadip (Recordati, Italy); Lercan (Recordati, Italy); Lercapin (Recordati, Italy); Lercaton (Recordati, Italy); Lerkamen (Recordati, Italy); Lerzam (Recordati, Italy); Renovia (Recordati, Italy); Vasodip (Recordati, Italy); Zandip (Recordati, Italy); Zanicor (Recordati, Italy).
Lercanidipine Preparation Products And Raw materials
Raw materials
Preparation Products
Lercanidipine Suppliers
Global(163)Suppliers
  • Supplier：
    career henan chemical co
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  • Advantage：58
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    Xiamen AmoyChem Co., Ltd
  • Tel：+86-86-5926051114<br/>+8615060885618
  • Email：sales@amoychem.com
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  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
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  • ProdList：32159
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  • Supplier：
    AFINE CHEMICALS LIMITED
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  • Email：sales@afinechem.com
  • Country：China
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Lercanidipine Spectrum
100427-26-7, LercanidipineRelated Search:
  • inhibitor
  • Inhibitors
  • 抑制剂
  • 药靶配体
  • 对照品
  • 医药原料
  • 对照品-杂质对照品
  • 小分子抑制剂
  • 医药中间体
  • 小分子抑制剂，天然产物
  • C36H41N3O6
  • 132566-11-6
  • 100472-26-7
  • 乐卡地平,10 MM DMSO 溶液
  • 3-(1-((3,3-二苯丙基)(甲基)氨基)-2-甲基丙-2-基) 5-甲基 2,6-二甲基-4-(3-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸酯
  • 乐卡地平|||MASNIDIPINE
  • 乐卡尼地平杂质
  • 乐卡地平
  • 乐卡地平杂质2
  • 乐卡地平13C-D3
  • 1,4-双氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸 2-[(3,3-二苯丙基)甲氨基]-1,1-二甲基乙基甲酯
  • 100427-26-7
  • Lercanidipine, 10 mM in DMSO
  • LercanidipineQ: What is Lercanidipine Q: What is the CAS Number of Lercanidipine Q: What is the storage condition of Lercanidipine
  • Lercanidipine USP/EP/BP
  • Lercanadipine
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester
  • 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Lercanidipine 13C-d3
  • LERCANIDIPINE(FORR&DONLY)
  • Rec-15-2375
  • Masnidipine
  • 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-[1,1-dimethyl-2-[methyl(3,3-diphenylpropyl)amino]ethyl] ester
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl]5-methyl ester
  • LercanidipineC36H41N306
  • methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITTROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-[(3,3-DIPHENYLPROPYL)METHYLAMINO]-1,1-DIMETHYLETHYL METHYL ESTER
  • LERCANIDIPINE

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