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ML346

ML346 Structure
ML346
  • CAS No.100872-83-1
  • Chemical Name:ML346
  • CBNumber:CB43041431
  • Molecular Formula:C14H12N2O4
  • Formula Weight:272.26
  • MOL File:100872-83-1.mol
ML346 Property
  • Melting point 266-268 °C(Solv: ethyl acetate (141-78-6))
  • Density 1.374±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility Soluble in DMSO:8.0(Max Conc. mg/mL);29.38(Max Conc. mM)
  • form A crystalline solid
  • pka 7.42±0.20(Predicted)
  • color Pink to red
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

ML346 Chemical Properties,Usage,Production

  • Description ML-346 is an activator of the heat shock response that induces the expression of the heat shock proteins HSP70, HSP40, and HSP27. It induces the expression of the oxidative stress response genes HO1, GCLM, and BiP in mouse embryonic fibroblasts (MEFs) and pretreatment protects cells from severe heat shock-induced death and H2O2-induced apoptosis. It promotes folding of metastable proteins in models of conformational disease, including cellular models of Huntingtin aggregation and cystic fibrosis. It reduces aggregate formation in PC12 cells expressing human Huntingtin exon 1 containing a 74 glutamine expansion when used at a concentration of 10 μM. It also corrects trafficking of cystic fibrosis transmembrane conductance regulator proteins bearing the F508 deletion (ΔF508-CFTR) mutation carried by the majority of cystic fibrosis patients, leading to increased cell surface expression.
  • Uses ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27[1].
  • in vivo

    ML346 suppress the aggregation of polyQ35 in a C. elegans model, suggesting the probe has efficacy in modifying protein aggregation and associated toxicity[1].

  • IC 50 HSP70: 4.6 μM (EC50, HeLa cells)
  • References [1] Calamini B, et al. ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases.Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2012 Dec 17. PMID:23833797
    [2] Calamini B, et al. Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol. 2011 Dec 25;8(2):185-96. DOI:10.1038/nchembio.763
ML346 Preparation Products And Raw materials
Raw materials
Preparation Products
ML346 Suppliers
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ML346 Spectrum
100872-83-1, ML346Related Search:
  • 抑制剂
  • 药靶配体
  • 对照品
  • 细胞生物学试剂
  • 化合物ML346,10 MM DMSO 溶液
  • 5-(3-(4-甲氧基苯基)烯丙亚基)嘧啶-2,4,6(1H,3H,5H)-三酮
  • 5-(3-(4-甲氧基苯基)烯丙基亚基)嘧啶-2,4,6(1H,3H,5H)-三酮
  • 化合物ML346
  • HSP70激动剂(ML346)
  • 5-[3-(4-甲氧基苯基)-2-丙烯-1-基]-2,4,6(1H,3H,5H)-嘧啶三酮
  • 100872-83-1
  • ML346, 10 mM in DMSO
  • response,inhibit,probe,protein,Heat shock proteins,Inhibitor,ML346,ML 346,HSP,shock,conformational,cytotoxicity,ML-346,heat,chaperones
  • 5-(3-(4-Methoxyphenyl)allylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-
  • CS-2056
  • ML346 - CID 767276
  • ML346;ML 346
  • ML346

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