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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Structure
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
  • CAS No.381168-77-0
  • Chemical Name:N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
  • CBNumber:CB04248334
  • Molecular Formula:C19H12F2N4
  • Formula Weight:334.32
  • MOL File:381168-77-0.mol
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Property
  • storage temp. Store at -20°C
  • solubility DMSO: ≥ 125 mg/mL (373.89 mM)
  • form Solid
  • color Light yellow to yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Chemical Properties,Usage,Production

  • Uses ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1].
  • Biological Activity ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.
  • in vitro

    ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.

    Western Blot Analysis

    < table class="zh_use_1"> Cell Line: HEK293T cells Concentration: 0-40 μM in the presence or absence of 20 μM 5-Furd Incubation Time: 16 hours Result: Inhibited the increased ATAD5 protein levels induced by 5-Furd.
  • target
  • References [1] Rohde JM, et al. Discovery of ML367, inhibitor of ATAD5 stabilization. Probe Reports from the NIH Molecular Libraries Program. PMID:24479200
    • N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Preparation Products And Raw materials
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    N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Spectrum
    381168-77-0, N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amineRelated Search:
    • 抑制剂
    • 药靶配体
    • C19H12F2N4
    • 化合物ML367,10 MM DMSO 溶液
    • N-(3,4-二氟苯基)-2-(吡啶-4-基)喹唑啉-4-胺
    • 化合物ML367
    • 381168-77-0
    • ML367, 10 mM in DMSO
    • ML-367,ML367,inhibit,ML 367,Inhibitor
    • 4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)-
    • ML367
    • N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

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    TargetValue
    ATAD5
    ()