N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- Product NameN-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- CAS381168-77-0
- CBNumberCB04248334
- MFC19H12F2N4
- MW334.32
- MOL File381168-77-0.mol
Chemical Properties
| storage temp. | Store at -20°C |
| solubility | DMSO: ≥ 125 mg/mL (373.89 mM) |
| form | Solid |
| color | Light yellow to yellow |
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Chemical Properties,Usage,Production
Uses
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1].Biological Activity
ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.in vitro
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.
Western Blot Analysis
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