ChemicalBook > CAS DataBase List > ML 18

ML 18

ML 18 Structure
ML 18
ML 18 Property
  • Boiling point 821.8±65.0 °C(Predicted)
  • Density 1.291±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: soluble
  • form A solid
  • pka 11.99±0.46(Predicted)
  • color White to yellow
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

ML 18 Chemical Properties,Usage,Production

  • Description ML-18 is a non-peptide bombesin receptor subtype 3 (BB3) antagonist that inhibits [125I]BA1 binding to NCI-H1299 lung cancer cells transfected with human BB3 receptors (IC50 = 4.8 μM). It is selective for BB3 over the gastrin releasing peptide receptor (GRPR) and the neuromedin B receptor (NMBR) with IC50 values of 16 and >100 μM, respectively, in a radioligand binding assay. ML-18 (16 μM) reversibly inhibits BA1-induced increases in cytosolic calcium in NCI-H1299 cells. It also inhibits BA1-induced phosphorylation of ERK and EGFR and reduces proliferation of NCI-H1299 cells.
  • Uses ML-18 is a non-peptide bombesin receptor subtype-3 antagonist. It also inhibits lung cancer growth.
ML 18 Preparation Products And Raw materials
Raw materials
Preparation Products
ML 18 Suppliers
Global(56)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：57505
  • Advantage：58
ML 18 Spectrum
1422269-30-4, ML 18Related Search:
  • 抑制剂
  • 合成有机化合物配体
  • 化合物ML 18,10 MM DMSO 溶液
  • ML 18,BRS-3拮抗剂
  • (S)-3-(1H-吲哚-3-基)-N-((1-(4-甲氧基苯基)环己基)甲基)-2-(3-(4-硝基苯基)脲基)丙酰胺
  • ML-18游离态
  • 化合物ML 18
  • 1422269-30-4
  • ML-18, 10 mM in DMSO
  • Bombesin Receptor,ML-18,ML 18,inhibit,Inhibitor,ML18
  • (S)-3-(1H-Indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide
  • (2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE
  • ML18, >98%
  • ML18;ML-18;ML 18;BRS-3 ANTAGONIST;1422269-30-4
  • BRS-3 antagonist
  • ML 18

Home

My