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CAY10603

CAY10603 Structure
CAY10603
  • CAS No.1045792-66-2
  • Chemical Name:CAY10603
  • CBNumber:CB42590439
  • Molecular Formula:C22H30N4O6
  • Formula Weight:446.5
  • MOL File:1045792-66-2.mol
CAY10603 Property
  • Density 1.231±0.06 g/cm3(Predicted)
  • storage temp. +2C to +8C
  • solubility ≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O
  • form Beige to light brown solid
  • pka 9.47±0.20(Predicted)
  • color White to light yellow
  • UNSPSC Code 12352200
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

CAY10603 Chemical Properties,Usage,Production

  • Description Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively). Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).
  • Uses HDAC6 Inhibitor is an inhibitor of HDAC6.
  • Definition ChEBI: N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester is a carbamate ester.
  • General Description A cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50<1.0 μM).
  • IC 50 HDAC6: 0.002 nM (IC50); HDAC3: 0.42 nM (IC50); HDAC10: 90.7 nM (IC50); HDAC2: 252 nM (IC50); HDAC1: 271 nM (IC50); HDAC8: 6851 nM (IC50)
CAY10603 Preparation Products And Raw materials
Raw materials
Preparation Products
CAY10603 Suppliers
Global(99)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
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  • Email：sales@invivochem.cn
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    Baynoe Chem (Suzhou) Co., Ltd.
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  • Email：sales06@baynoe.com
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    LEAP CHEM CO., LTD.
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  • Supplier：
    Aladdin Scientific
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  • Email：tp@aladdinsci.com
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CAY10603 Spectrum
1045792-66-2, CAY10603Related Search:
  • Inhibitors
  • 抑制剂
  • 合成有机化合物配体
  • 标准品
  • 细胞生物学试剂
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • 化合物CAY10603,10 MM DMSO 溶液
  • 化合物CAY10603
  • (4-(3-((7-(羟基氨基)-7-氧代庚基)氨基甲酰)异恶唑-5-基)苯基)氨基甲酸叔丁酯
  • HDAC6抑制剂(CAY10603)
  • N-[4-[3-[[[7-(羟基氨基)-7-氧代庚基]氨基]羰基]-5-异恶唑基]苯基]氨基甲酸叔丁酯
  • 1045792-66-2
  • Histone Deacetylase Inhibitor VIII
  • CAY10603, 10 mM in DMSO
  • CAY10603 CAY10603
  • BML 281,inhibit,Histone deacetylases,BML281,CAY-10603,Inhibitor,CAY10603,CAY 10603,HDAC
  • Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester
  • BML-281
  • tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate
  • 187257
  • CAY10603; CAY-10603; CAY 10603.
  • Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem
  • HDAC6 Inhibitor
  • tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate
  • Isox
  • CAY10603
  • HDAC6 inhibitor ISOX
  • N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]carbamic acid 1,1-dimethylethyl ester

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