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Nexturastat A

Nexturastat A Structure
Nexturastat A
  • CAS No.1403783-31-2
  • Chemical Name:Nexturastat A
  • CBNumber:CB52715657
  • Molecular Formula:C19H23N3O3
  • Formula Weight:341.4
  • MOL File:1403783-31-2.mol
Nexturastat A Property
  • Density 1.228±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility insoluble in H2O; ≥16.3 mg/mL in DMSO; ≥9.3 mg/mL in EtOH
  • form solid
  • pka 8.95±0.10(Predicted)
  • color White to off-white
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P280-P305+P351+P338

Nexturastat A Chemical Properties,Usage,Production

  • Uses Nexturastat A is a potent and selective histone deacetylase 6 (HDAC6) inhibitor that shows potential antiproliferative effects against melanoma cells.
  • Biological Activity nexturastat a is a selective inhibitor of histone deacetylase 6 (hdac6) with ic50 value of 5.2 nm [1].nexturastat a is a hdac inhibitor. it was developed by structural modification of aryl urea hdacis. the inhibitory activity of nexturastat a is most potent against hdac6 with ic50 value of 5.2 nm. besides that, nexturastat a also shows inhibition of other hdacs with ic50 values of 3.02, 6.92, 6.68, 9.39, 11.7, 4.46, 0.954, 6.72, 7.57 and 5.14 μm for hdac1, 2, 3, 4, 5, 7, 8, 9, 10 and 11, respectively. nexturastat a has been shown to suppress cell proliferation and promote apoptosis in b16 murine melanoma cells [1, 2].
  • in vivo

    Nexturastat A (NexA) (every two days, 20 days) inhibits tumor growth in murine xenograft models of MM[2].

  • target HDAC6
  • IC 50 HDAC6: 5.02 nM (IC50); HDAC8: 0.954 μM (IC50); HDAC1: 3.02 μM (IC50); HDAC7: 4.46 μM (IC50); HDAC11: 5.14 μM (IC50); HDAC3: 6.68 μM (IC50); HDAC9: 6.72 μM (IC50); HDAC2: 6.92 μM (IC50); HDAC10: 7.57 μM (IC50); HDAC4: 9.39 μM (IC50); HDAC5: 11.7 μM (IC50)
  • References [1] kalin j h, bergman j a. development and therapeutic implications of selective histone deacetylase 6 inhibitors. journal of medicinal chemistry, 2013, 56(16): 6297-6313.
    [2] zhang l, han y, jiang q, et al. trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy. medicinal research reviews, 2014.
Nexturastat A Preparation Products And Raw materials
Raw materials
Preparation Products
Nexturastat A Suppliers
Global(110)Suppliers
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    career henan chemical co
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    Aladdin Scientific
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Nexturastat A Spectrum
1403783-31-2, Nexturastat ARelated Search:
  • Inhibitors
  • 抑制剂
  • 合成有机化合物配体
  • 合成材料中间体
  • 标准品
  • 细胞生物学试剂
  • 小分子抑制剂
  • 小分子抑制剂，天然产物
  • 化合物NEXTURASTAT A,10 MM DMSO 溶液
  • 化合物CALPEPTIN
  • 化合物NEXTURASTAT A
  • 4-((1-丁基-3-苯基脲基)甲基)-N-羟基苯甲酰胺
  • 4-((1-丁基-3-苯脲基)甲基)-N-羟基苯甲酰胺
  • HDAC6抑制剂(NEXTURASTAT A)
  • 4-[[丁基[(苯基氨基)羰基]氨基]甲基]-N-羟基苯甲酰胺
  • 1403783-31-2
  • Nexturastat A, 10 mM in DMSO
  • Nexturastat A (AG-CR1-3901)
  • Nextunastat A
  • Nexturastat A, >97%
  • CS-1289
  • 4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
  • Nexturastat A Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-
  • Nexturastat A 4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE
  • Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-
  • 4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE
  • Nexturastat A
  • 4-[[Butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxybenzamide
  • Nexturastat A, >=98%

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