ChemicalBook > CAS DataBase List > YS 49

YS 49

YS 49 Structure
YS 49
  • CAS No.132836-42-1
  • Chemical Name:YS 49
  • CBNumber:CB41390234
  • Molecular Formula:C20H20BrNO2
  • Formula Weight:386.2823
  • MOL File:132836-42-1.mol
YS 49 Property
  • storage temp. 2-8°C
  • solubility H2O: >10mg/mL
  • form solid
  • color White to off-white
  • Water Solubility H2O: >10mg/mL
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn,N
  • Risk Statements  :22-50
  • Safety Statements  :61
  • RIDADR  :UN 3077 9 / PGIII
  • WGK Germany  :3
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements

YS 49 Chemical Properties,Usage,Production

  • Biological Activity YS-49 is an activator of PI3K/Akt, a downstream target of RhoA, and reduces RhoA/PTEN activation in 3-methylcholine-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated VSMC proliferation by inducing heme oxygenase (HO-1). YS-49 is an isoquinoline compound alkaloid with strong positive inotropic effects due to its ability to activate cardiac β-adrenoceptors.
  • in vitro

    YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC 50 values of 22 μM and 30 μM, respectively.
    YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.

    Cell Viability Assay

    Cell Line: RAVSMC and RAW 264.7 cells
    Concentration: 10 μM, 30 μM and 100 μM (RAVSMC cells); 1 μM, 10 μM and 100 μM (RAW 264.7 cells)
    Incubation Time: 18 hours
    Result: Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC 50 values of 22 and 30 μM, respectively .

    Western Blot Analysis

    Cell Line: RAVSMC and RAW 264.7 cells
    Concentration: 10 μΜ, 30 μΜ and 100 μΜ
    Incubation Time: 18 hours
    Result: Concentration -dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ.
  • in vivo

    YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM. < /p>

    < tr>
    Animal Model: Male Sprague Dawley rats (250-300 g)
    Dosage: 5 mg/kg
    Administration: Intraperitoneal injection; 8 hours
    Result: Serum NOx levels were significantly reduced.
YS 49 Preparation Products And Raw materials
Raw materials
Preparation Products
YS 49 Suppliers
Global(86)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Career Henan Chemica Co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：laboratory@coreychem.com
  • Country：China
  • ProdList：30231
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
  • Supplier： MedChemexpress LLC
  • Tel：021-58955995
  • Email：sales@medchemexpress.cn
  • Country：United States
  • ProdList：4861
  • Advantage：58
YS 49 Spectrum
132836-42-1, YS 49Related Search:
  • PI3K/Akt/mTOR
  • PI3K
  • mTOR
  • Akt
  • 抑制剂
  • C20H19NO2HBr
  • 化合物YS-49,10 MM DMSO 溶液
  • 1-(萘-1-基甲基)-1,2,3,4-四氢异喹啉-6,7-二醇氢溴酸盐
  • 化合物YS-49
  • 1,2,3,4-四氢-1-(1-萘基甲基)-6,7-异喹啉二醇氢溴酸盐
  • 132836-42-1
  • YS-49, 10 mM in DMSO
  • inhibit,YS-49,PI3K,Adrenergic Receptor,Phosphoinositide 3-kinase,PKB,Beta Receptor,YS 49,Akt,Protein kinase B,Inhibitor,YS49,Angiotensin Receptor
  • YS 49;YS49
  • CS-884
  • 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide
  • 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate
  • YS 49

Home

My