ChemicalBook > CAS DataBase List > Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-

Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-

CAS No.1318793-78-0
Chemical Name:Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-
CBNumber:CB611360694
Molecular Formula:C42H77NO2
Formula Weight:628.07
MOL File:1318793-78-0.mol

Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- Property

Boiling point 663.6±55.0 °C(Predicted)
Density 0.91±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Ethanol: 25 mg/ml
pka 7.51±0.10(Predicted)
form Liquid
color Colorless to light yellow

Safety

NFPA 704:

	3
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H225-H319
Precautionary statements P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501

Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- Chemical Properties,Usage,Production

Uses YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo[1].
Biological Activity YSK05 is an ionizable amino lipid (apparent pKa = ~6.5) that has been used in combination with other lipids in the formation of liposomes and lipid nanoparticles (LNPs).1,2,3 Administration of cyclic di-GMP in YSK05-containing liposomes increases serum levels of IFN-β, IFN-γ, IL-6, and TNF-α and activates natural killer (NK) cells in mice, as well as decreases lung metastasis in a B16/F10 murine melanoma model of metastasis.2 Intravenous administration of factor VII siRNA in YSK05-containing LNPs reduces factor VII activity in isolated mouse plasma.3
References 1.Sato, Y., Hatakeyama, H., Sakurai, Y., et al.A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivoJ. Control. Release163(3)267-276(2012) 2.Nakamura, T., Miyabe, H., Hyodo, M., et al.Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanomaJ. Control. Release216149-157(2015) 3.Sato, Y., Note, Y., Maeki, M., et al.Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA deliveryJ. Control. Release22948-57(2016)

Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- Preparation Products And Raw materials

Raw materials

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