Description In vitro In vivo
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Y320

Description In vitro In vivo
Y320 Structure
Y320
  • CAS No.288250-47-5
  • Chemical Name:Y320
  • CBNumber:CB62685328
  • Molecular Formula:C27H29ClN6O2
  • Formula Weight:505.01
  • MOL File:288250-47-5.mol
Y320 Property
  • Boiling point 631.2±55.0 °C(Predicted)
  • Density 1.34±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility ≥24.8 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
  • form solid
  • pka 11.82±0.70(Predicted)
  • color Off-white to pink
  • FDA UNII 82S7NR4B46
  • UNSPSC Code 12352200
  • NACRES NA.21
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319
  • Precautionary statements P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Y320 Chemical Properties,Usage,Production

  • Description Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.
  • In vitro Y-320 also inhibits the production of IFN-γ and TNF-α by mouse CD4 T cells stimulated with IL-15, CXCL12, and anti-CD3 mAb.
  • In vivo Y-320 (0.3-3 mg/kg p.o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys. Moreover, Y-320 shows a synergistic effect in combination with anti-TNF-α mAb on chronic-progressing CIA in mice.
  • Uses 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide inhibits T cell activation induced by IL-15 and shows a therapeutic effect on collagen-induced arthritis in DBA/1J mice.
  • Biological Activity y-320 is a new phenylpyrazoleanilide immunomodulator [1].immunotherapy refers to treatment of disease by suppressing, inducing or enhancing an immune response.y-320 is a new phenylpyrazoleanilide immunomodulator. y-320 inhibited il-17 production by cd4 t cells induced by il-15 with ic50 values of 20-60 nm [1].in type ii collagen-induced arthritis (cia) mice, oral administration of y-320 (0.3-3 mg/kg) reduced il-17 mrna expression and significantly inhibited the development of joint destruction and arthritis. the combination of y-320 with anti-murine tumor necrosis factor-α (tnf-α) monoclonal antibody exhibited a synergistic effect. in cynomolgus monkeys, y-320 (0.3-1 mg/kg) relieved cia. these results suggested that y-320 could be a useful candidate for therapy of rheumatoid arthritis (ra) [1].
  • in vivo

    Y-320 (0-3 mg/kg; p.o.; daily, for 42 d) ameliorates collagen-induced arthritis (CIA) in DBA/1J mice with a reduction of IL-17 mRNA in arthritic joints[1].
    Y-320 (5 mg/kg; i.v.; every three days, for 18 d; Homozygous nude athymic mice with Bats-72 xenograft) sensitizes MDR xenograft tumor to Paclitaxel in vivo[3].

    Animal Model:Type II collagen-induced arthritis (CIA) in DBA/1J mice[1]
    Dosage:0, 0.1, 0.3, 1, and 3 mg/kg
    Administration:Oral administration; daily, for 42 days
    Result:Inhibited the development of CIA and the increase in paw thickness in a dose-dependent manner.
    Inhibited joint destructions in a dose-dependent manner.
    Improved inflammation and damage in the arthritic ankle joints in CIA mice.
    Animal Model:Homozygous nude athymic mice with Bats-72 xenograft (female, 4-5 weeks old)[3]
    Dosage:5 mg/kg; Paclitaxel (5 mg/kg)
    Administration:Intravenous injection; every three days, for 18 days
    Result:Inhibited tumor growth in Bats-72 xenografts without severe adverse effects.
  • IC 50 IL-15; IL-17
  • References [1]. ushio h, ishibuchi s, oshita k, et al. a new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. pharmaceuticals (basel), 2013, 7(1): 1-17.
Y320 Preparation Products And Raw materials
Raw materials
Preparation Products
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Y320 Spectrum
288250-47-5, Y320Related Search:
  • Inhibitors
  • 抑制剂
  • 药靶配体
  • 小分子抑制剂
  • 小分子抑制剂，天然产物
  • C27H29ClN6O2
  • 化合物Y320,10 MM DMSO 溶液
  • 化合物Y320
  • 1-(4-氯苯基)-N-(3-氰基-4-(4-吗啉哌啶-1-基)苯基)-5-甲基-1H-吡唑-4-甲酰胺
  • 1-(4-氯苯基)-N-[3-氰基-4-[4-(4-吗啉基)-1-哌啶基]苯基]-5-甲基-1H-吡唑-4-甲酰胺
  • 288250-47-5
  • Y-320, 10 mM in DMSO
  • 1-(4-chlorophenyl)-N-{3-cyano-4-[4-(morpholin-4-yl)piperidin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide
  • 1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-
  • Y320; Y 320
  • 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxami
  • Y-320, >=98%
  • Y320 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide
  • 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320
  • 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-car
  • 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide
  • 1-(4-CHLOROPHENYL)-N-(3-CYANO-4-(4-MORPHOLINOPIPERIDIN-1-YL)PHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE
  • Y320

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