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YH239-EE

YH239-EE Structure
YH239-EE
  • CAS No.1364488-67-4
  • Chemical Name:YH239-EE
  • CBNumber:CB82710411
  • Molecular Formula:C25H27Cl2N3O4
  • Formula Weight:504.41
  • MOL File:1364488-67-4.mol
YH239-EE Property
  • Boiling point 763.3±60.0 °C(Predicted)
  • Density 1.313±0.06 g/cm3(Predicted)
  • storage temp. Desiccate at -20°C
  • solubility ≥50.4 mg/mL in DMSO; insoluble in H2O; ≥4.26 mg/mL in EtOH with ultrasonic
  • form solid
  • pka 13.20±0.30(Predicted)
  • color White to off-white
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements
  • Precautionary statements

YH239-EE Chemical Properties,Usage,Production

  • Uses YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
  • Biological Activity yh239-ee is a potent antagonist of p53-mdm2 [1].p53 is a transcription factor and functions as a tumor suppressor. mdm2 is a negative regulator of p53. the interaction of p53 and mdm2 has emerged as a novel target for anticancer drugs [1].yh239-ee is a potent p53-mdm2 antagonist. in oci-aml-3 cells, yh239-ee potently inhibited cell proliferation. in aml cell lines, yh239-ee induced a cell cycle arrest and cell accumulation in the sub-g1 phase. yh239-ee induced apoptosis by 11.8-fold, 5.6-fold and 13.1-fold in oci-aml-3, molm-13 and nb4 aml cell lines, respectively. in molm-13 cells, yh239 exhibited almost no apoptotic effect. however, yh239-ee significantly induced apoptosis. in molm-13 cells, (+)-yh239-ee and (−)-yh239-ee inhibited metabolic activity with ec50 values of 7.5 μm and 25.2 μm and induced apoptosis with 13.7% and 51.5% viable cells, respectively. (+)-yh239-ee (20 μm) induced p53 and significantly activated caspase 3 and 7 [1].
  • target p53-MDM2
  • storage Store at -20°C
  • References [1]. huang y, wolf s, beck b, et al. discovery of highly potent p53-mdm2 antagonists and structural basis for anti-acute myeloid leukemia activities. acs chem biol, 2014, 9(3): 802-811.
YH239-EE Preparation Products And Raw materials
Raw materials
Preparation Products
YH239-EE Suppliers
Global(93)Suppliers
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    TargetMol Chemicals Inc.
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    TargetMol Chemicals Inc.
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    Aladdin Scientific
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YH239-EE Spectrum
1364488-67-4, YH239-EERelated Search:
  • Inhibitors
  • 抑制剂
  • 药靶配体
  • 小分子抑制剂，天然产物
  • C25H27Cl2N3O4
  • 化合物YH239-EE,10 MM DMSO 溶液
  • YH 239-EE,MDM2抑制剂
  • 3-(2-(叔丁胺)-1-(N-(4-氯苄基)甲酰胺)-2-氧代乙基)-6-氯-1H-吲哚-2-羧酸乙酯
  • YH239-EE,YH239乙酯
  • 化合物YH239-EE
  • 1364488-67-4
  • YH239-EE, 10 mM in DMSO
  • YH239-EE USP/EP/BP
  • 1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester
  • CS-1286
  • YH 239-EE;YH 239 EE
  • YH239-EE
  • Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-
  • ethyl 3-[2-(tert-butylamino)-1-[(4-chlorophenyl)methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate
  • YH239-EE 6-Chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid Ethyl Ester
  • Ethyl 3-[2-(tert-Butylamino)-1-[N-(4-chlorobenzyl)formamido]-2-oxoet
  • YH239-EE ethyl 3-[2-(tert-butylamino)-1-[(4-chlorophenyl)methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate
  • Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate

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