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Fluocortolone

Fluocortolone Structure
Fluocortolone
  • CAS No.152-97-6
  • Chemical Name:Fluocortolone
  • CBNumber:CB3378252
  • Molecular Formula:C22H29FO4
  • Formula Weight:376.46
  • MOL File:152-97-6.mol
Fluocortolone Property
  • Melting point 113-116°C
  • alpha D20 +100° (dioxane)
  • Boiling point 537.4±50.0 °C(Predicted)
  • Density 1.1001 (estimate)
  • vapor pressure 0.001Pa at 25℃
  • storage temp. Refrigerator
  • solubility Chloroform (Slightly), Dioxane (Slightly), Methanol (Slightly)
  • form Solid
  • pka 12.98±0.10(Predicted)
  • color Pale Yellow to Yellow
  • Water Solubility 204mg/L at 20℃
  • LogP 2.3 at 25℃
  • FDA UNII 65VXC1MH0J
  • ATC code C05AA08,D07AC05,D07XC05,H02AB03
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H360-H301-H372
  • Precautionary statements P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P314-P501

Fluocortolone Chemical Properties,Usage,Production

  • Chemical Properties Pale Yellow Solid
  • Originator Ultralan,Schering,W. Germany,1965
  • Uses Fluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids. Fluocortolone is similar to Fluocortin, but with one less keto group.
  • Definition ChEBI: Fluocortolone is a 21-hydroxy steroid.
  • Manufacturing Process (a) 16α-Methyl-6α-Fluoro-δ4-11β,21-Diol-3,20-Dione:16α-methyl-6α-fluoro-δ4- pregnene-21-ol-3,20-dione-21-acetate (MP 132°/134° to 138°C, UVε238= 15,000) is hydroxylated with Curvularia lunata in 11β-position using the fermentation method whereby the 21-acetate group is simultaneously saponified. The hitherto unknown starting material 16α-methyl-6α-fluoro-δ4- pregnene-21-ol-3,20-dione-21-acetate is obtained from 16α-methyl-δ5- pregnene-3β,21-diol-20-one-21-acetate, MP 152° to 154°C, by the addition of bromofluorine (from N-bromoacetamide and hydrogen fluoride) onto the 5-6 double bond, oxidation of the 3β-hydroxyl group with chromic acid, introduction of the δ4-double bond by splitting of the hydrogen bromide and acid isomerization of the 6β-fluoro substituent to the 16α-methyl-6α-fluoro-δ4- pregnene-21-ol-3,20-dione-21-acetate. By chromatographic purification on silica gel the 16α-methyl-6α-fluoro-δ4-pregnene-11β,21-diol-3,20-dione is: MP 166°/167° to 171°C.
    (b) 16α-Methyl-6α-Fluoro-δ4-Pregnene-11β,21-Diol-3,20-Dione-21-Acetate:By reaction of the compound of (a) with acetic anhydride in pyridine at room temperature, the acetate is obtained and recrystallized from ethyl acetate, MP 248°/249° to 251°C.
    (c) 16α-Methyl-6α-Fluoro-δ1,4-Pregnadiene-11β,21-Diol-3,20-Dione:16α- methyl-6α-fluoro-δ4-pregnene-11β,21-diol-3,20-dione is dehydrogenated with Corynebacterium simplex. The extraction residue is subjected to chromatography on silica gel and after recrystallization there is obtained from methylene chloride-isopropyl ether 16α-methyl-6α-fluoro-δ1,4-pregnadiene- 11β,21-diol-3,20-dione, MP 180°/181° to 182°C.
  • Therapeutic Function Glucocorticoid
  • Flammability and Explosibility Not classified
Fluocortolone Preparation Products And Raw materials
Raw materials
Preparation Products
Fluocortolone Suppliers
Global(57)Suppliers
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    GIHI CHEMICALS CO.,LIMITED
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  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：57505
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Fluocortolone Spectrum
152-97-6, FluocortoloneRelated Search:
  • Steroids
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • 杂质对照品
  • 医药原料
  • 高端化学
  • 甾体化合物
  • C22H29FO4
  • 氟可龙新戊酸 EP 杂质 A(氟可龙)
  • 氟可龙三甲基乙酸盐杂质1 (氟可龙三甲基乙酸盐EP杂质A)(氟可龙)
  • 氟考酮新戊酸酯EP杂质A(氟考酮)
  • 氟可龙杂质13
  • 特戊酸氟可龙EP杂质A
  • 氟皮甾松
  • 氟可套龙
  • 氟考松
  • 氟可龙
  • 152-97-6
  • Fluocortolone Pivalate Impurity 1 (Fluocortolone Pivalate EP Impurity A)(Fluocortolone)
  • Fluocortolone Pivalate EP Impurity A (Fluocortolone)
  • Fluocortolone Impurity 13
  • flucortolone
  • FLUORCORTOLONE
  • Fluocortolone USP/EP/BP
  • Fluocortolone Pivalate EP Impurity A
  • Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)-
  • Fluocortolone (Fluocortolone Pivalate EPImpurity A)
  • 6-fluoro-11-hydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
  • FLUOCORTOLONE
  • 17alpha-propyl-5alpha-androstan-3-one
  • 16α-Methyl-6α-fluoro-1,4-pregnadien-11β,21-diol-3,20-dione
  • (6α,11β,16α)-6-Fluoro-11,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione
  • (6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-17-glycoloyl-11-hydroxy-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
  • (6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
  • (6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
  • SH-742
  • SH 742
  • Fluorocortolone
  • Fluocortolon
  • methylfluorodehydrocorticosterone
  • 6-alpha-fluoro-11-beta,21-dihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
  • (6s,8s,9r,10s,11s,13s,14s,16r,17s)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one

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