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Paramethasone

Paramethasone Structure
Paramethasone
  • CAS No.53-33-8
  • Chemical Name:Paramethasone
  • CBNumber:CB0301372
  • Molecular Formula:C22H29FO5
  • Formula Weight:392.46
  • MOL File:53-33-8.mol
Paramethasone Property
  • Melting point 228-241°C
  • Boiling point 573.5±50.0 °C(Predicted)
  • Density 1.32±0.1 g/cm3(Predicted)
  • storage temp. -20°C Freezer
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • pka 12.34±0.70(Predicted)
  • color White to Pale Beige
  • CAS DataBase Reference 53-33-8
  • FDA UNII VFC6ZX3584
  • ATC code H02AB05
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Paramethasone Chemical Properties,Usage,Production

  • Originator Haldrone,Lilly,US,1961
  • Uses Paramethasone, is a fluorinated glucocorticoid, having anti-inflammatory and immunosuppressant properties.
  • Uses Glucocorticoid.
  • Definition ChEBI: Paramethasone is a fluorinated steroid.
  • Manufacturing Process A solution of 0.144 g of the 3-ethylene glycol ketal of 5α,11β,17α,21 tetrahydroxy-6β-fluoro-16α-methylallopregnane-3,20-dione-21 acetate in 12 ml of chloroform and 0.1 ml of absolute alcohol was cooled to -10°C in an icesalt bath and a stream of anhydrous hydrochloric acid was gently bubbled through the solution for 2.5 hours while the temperature was maintained between -5°C and -15°C. The solution was then diluted with 25 ml of chloroform, washed with dilute sodium bicarbonate and water, dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure at 60°C or less to give 6α-fluoro-11β,17α,21-trihydroxy-16α-methyl-4-pregnene3,20-dione 21-acetate.
  • brand name Haldrone (Lilly).
  • Therapeutic Function Glucocorticoid
Paramethasone Preparation Products And Raw materials
Raw materials
Preparation Products
Paramethasone Suppliers
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Paramethasone Spectrum
53-33-8, ParamethasoneRelated Search:
  • 原料药
  • FPMS06(氟帕米松)
  • 甲泼尼龙杂质30 (帕拉米松)
  • 化合物 T33883L
  • 帕拉米松 标准品
  • 帕拉米松
  • 帕那麦载松
  • 53-33-8
  • Picaridin Impurity 9
  • 1, 4-PREGNADIEN-6α-FLUORO-16α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE
  • Methylprednisolone Impurity 30 (Paramethasone)
  • Pregna-1,4-diene-3,20-dione,6-fluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)-
  • Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-
  • 6-fluoro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • 1,4-PREGNADIEN-6-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE
  • 6-alpha-fluoro-16-alpha-methylprednisolone
  • 6-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
  • 6a-fluoro-11b,17a,21-trihydroxy-16a-methyl-1,4-pregnadiene-3,20-dione
  • PARAMETHASONE
  • 6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
  • (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)- (9CI)
  • Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16-methyl- (7CI)
  • Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16a-methyl- (8CI)
  • Cortiden
  • 6a-Fluoro-16a-methylprednisolone
  • 16a-Methyl-6a-fluoroprednisolone

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