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Schisandrin

CAS No.7432-28-2
Chemical Name:Schisandrin
CBNumber:CB3334838
Molecular Formula:C24H32O7
Formula Weight:432.51
MOL File:7432-28-2.mol

Schisandrin Property

Melting point 128.5°C
Boiling point 466.17°C (rough estimate)
Density 1.1480 (rough estimate)
refractive index 1.5800 (estimate)
storage temp. 2-8°C
solubility DMSO: ≥13mg/mL
pka 14.58±0.40(Predicted)
form powder
color white to beige
optical activity [α]/D 75 to 95°, c = 1 in methanol
InChIKey YEFOAORQXAOVJQ-UHFFFAOYSA-N
LogP 3.153 (est)
FDA UNII G01BQC0879
UNSPSC Code 41116107
NACRES NA.77

Safety

Hazard Codes :Xn,N
Risk Statements :22-50/53
Safety Statements :60-61
RIDADR :UN 3077 9 / PGIII
WGK Germany :3
HS Code :29093090

NFPA 704:

	0
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H400
Precautionary statements P301+P312+P330-P273

Schisandrin Price More Price(2)

Brand: Sigma-Aldrich(India)
Product number: SML0054
Product name : Schizandrin
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: ₹7967.2
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: SML0054
Product name : Schizandrin
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: ₹32345.1
Updated: 2022/06/14
Buy: Buy

Schisandrin Chemical Properties,Usage,Production

Description Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities. It induces cell cycle arrest at the G₀/G₁ phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM. Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells. It reduces apoptosis induced by cisplatin in HK-2 human kidney cells. In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats. It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.
Uses Schizandrin may be used in oxidative stress-related cell signaling studies.
Application Schizandrin is a natural compound that belongs to the group of schisandrins. Schizandrins are a class of compounds with biochemical properties and biological activities, such as anti-inflammatory, antioxidant, and anti-cancer effects. This compound has been shown to have pro-apoptotic properties in a model system. It has also demonstrated the ability to inhibit influenza A virus replication in vitro and protect mice against Listeria monocytogenes infection. It can be used as an inhibitor of gsh-px activity in myocardial infarcts.
Definition ChEBI: Schizandrin is a tannin.
Biochem/physiol Actions Schizandrin is a natural product with several biological properties involved with antioxidant and anti-inflammatory activities. It reduces the formation of ROS, inhibits the mitochondrial pathway of the apoptotic process and oxidative stress. Schizandrin has been reported to have hepatoprotective, antitumor, antiviral, and antiamnesic effects, and has neuroprotective activity against glutamate induced neurotoxicity.