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WH-4-023

WH-4-023 Structure
WH-4-023
  • CAS No.837422-57-8
  • Chemical Name:WH-4-023
  • CBNumber:CB32710784
  • Molecular Formula:C32H36N6O4
  • Formula Weight:568.67
  • MOL File:837422-57-8.mol
WH-4-023 Property
  • Boiling point 743.2±70.0 °C(Predicted)
  • Density 1.247±0.06 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility Soluble in DMSO (60 mg/ml)
  • pka 7.89±0.42(Predicted)
  • form powder
  • color white to beige
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • RIDADR  :UN 2811 6.1 / PGIII
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301
  • Precautionary statements P264-P270-P301+P310-P405-P501
WH-4-023 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1334
  • Product name : WH-4-023
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹13908.3
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1334
  • Product name : WH-4-023
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹55932.9
  • Updated: 2022/06/14
  • Buy: Buy

WH-4-023 Chemical Properties,Usage,Production

  • Description WH-4-23 (837422-57-8) is a potent and selective inhibitor of Src family kinases Lck and Src, IC50=2 and 6 nM respectively.1,2 Also inhibits SIK, IC50=10, 22 and 60 nM for SIK 1, 2 and 3 respectively.3 May be used along with PD-325901 and CHIR-99021 to support self-renewal of na?ve human embryonic stem cells.4
  • Uses WH-4-023 is a potent and selective dual lymphocyte-specific kinase (Lck) inhibitor.
  • Definition ChEBI: N-(2,4-dimethoxyphenyl)-N-[2-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]carbamic acid (2,6-dimethylphenyl) ester is a member of piperazines.
  • Biochem/physiol Actions WH-4-023 (KIN112) is a potent and selective inihbitor of the tyrosine kinases Lck and Src with IC50 values of 2 nM for Lck and 6 nM for Src. WH-4-023 is a somewhat less potent inhibitor of salt-inducible kinases (SIKs) with IC50 values of 10, 22 and 60 nM for SIK 1, 2 and 3 respectively. WH-4-023 was found to support self-renewal of naive human embryonic stem cells, in particular in combination with PD 0325901 (PZ0162), CHIR99021 (SML1046), and SB-590885 (SML0501).
  • storage Store at -20°C
  • References Martin et al. (2006), Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity; J. Med. Chem., 49 4981 Moroco et al. (2015), A discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region; Chem. Biol. Drug. Des., 86 144 Clark et al. (2012), Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages; Proc. Natl. Acad. Sci. USA, 109 16986 Theunissen et al. (2014), Systemic identification of culture conditions for introduction and maintenance of na?ve human pluripotency; Cell Stem Cell, 15 471
WH-4-023 Preparation Products And Raw materials
Raw materials
Preparation Products
WH-4-023 Suppliers
Global(129)Suppliers
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
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  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
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  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
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  • Supplier：
    Coresyn Pharmatech Co., Ltd.
  • Tel：+86-571-86626709<br/>+86-18157142896
  • Email：cbc@coresyn.com
  • Country：China
  • ProdList：9984
  • Advantage：58
WH-4-023 Spectrum
837422-57-8, WH-4-023Related Search:
  • API
  • Inhibitors
  • 抑制剂
  • 化工试剂
  • 合成有机化合物配体
  • 标准品
  • 细胞生物学试剂
  • 小分子抑制剂
  • 小分子抑制剂，天然产物
  • 化合物WH-4-023,10 MM DMSO 溶液
  • WH-4-023,LCK和SRC抑制剂
  • WH-4-023游离
  • 化合物WH-4-023
  • (2,4-二甲氧基苯基)(2-((4-(4-甲基哌嗪-1-基)苯基)氨基)嘧啶-4-基)氨基甲酸-2,6-二甲基苯酯
  • LCK/SRC抑制剂(WH-4-023)
  • 2,6-二甲基苯基 N-[2,4-二(甲氧基)苯基][2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基甲酸酯
  • 837422-57-8
  • WH-4-023, 10 mM in DMSO
  • WH-4-023 USP/EP/BP
  • 2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)carbamate
  • )amino)pyrimidin-4-yL
  • )(2-((4-(4-methyL
  • DUAL LCK/SRC INHIBITOR;KIN001-112; KIN112
  • 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate
  • WH-4-024
  • CS-1827
  • DUAL LCK/SRC INHIBITOR
  • WH-4-023
  • 2,6-Dimethylphenyl N-[2,4-bis(methyloxy)phenyl][2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate
  • 2,6-Dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-
  • WH-4-023, 837422-57-8
  • WH-4-023, >=98%
  • WH-4-023 2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE
  • 2,6-dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)carbamate WH-4-023
  • KIN112
  • KIN001-112
  • Carbamic acid, N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-, 2,6-dimethylphenyl ester
  • 2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE

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