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Saracatinib

Saracatinib Structure
Saracatinib
  • CAS No.379231-04-6
  • Chemical Name:Saracatinib
  • CBNumber:CB61518531
  • Molecular Formula:C27H32ClN5O5
  • Formula Weight:542.03
  • MOL File:379231-04-6.mol
Saracatinib Property
  • Melting point 84-89°C
  • Boiling point 671.2±55.0 °C(Predicted)
  • Density 1.348
  • storage temp. -20°C
  • solubility Soluble in DMSO (50 mg/ml) and ethanol (54 mg/mL with warming)
  • form solid
  • pka 7.55±0.10(Predicted)
  • color White
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
  • FDA UNII 9KD24QGH76
  • NCI Drug Dictionary saracatinib
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H317-H319
  • Precautionary statements P280-P305+P351+P338

Saracatinib Chemical Properties,Usage,Production

  • Description Saracatinib is a dual inhibitor of the tyrosine kinases c-Src and Abl (IC50 = 2.7 and 30 nM, respectively). It less effectively inhibits other receptor and non-receptor tyrosine kinases as well as assorted serine/threonine kinases. Saracatinib is orally available and blocks cell motility, migration, adhesion, invasion, proliferation, differentiation, and survival. Through its effects on c-Src, it reduces osteoclast bone resorption. Saracatinib also blocks denque virus RNA replication through its effect on Fyn kinase.
  • Chemical Properties White Solid
  • Uses An oral, selective dual inhibitor of Src and ABL kinase. It is a COVID19-related research product.
  • Definition ChEBI: Saracatinib is a member of the class of quinazolines that is quinazoline substituted by (5-chloro-2H-1,3-benzodioxol-4-yl)amino, (oxan-4-yl)oxy and 2-(4-methylpiperazin-1-yl)ethoxy groups at positions 4, 5 and 7, respectively. It is a dual inhibitor of the tyrosine kinases c-Src and Abl (IC50 = 2.7 and 30 nM, respectively). Saracatinib was originally developed by AstraZeneca for the treatment of cancer but in 2019 it was granted orphan drug designation by the US Food and Drug Administration for the treatment of idiopathic pulmonary fibrosis (IPF), a type of lung disease that results in scarring (fibrosis) of the lungs. It has a role as an antineoplastic agent, an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, a radiosensitizing agent, an autophagy inducer, an apoptosis inducer and an anticoronaviral agent. It is a member of quinazolines, a secondary amino compound, a N-methylpiperazine, an aromatic ether, a member of oxanes, a member of benzodioxoles, an organochlorine compound and a diether.
  • storage Store at -20°C
  • References Hennequin et al. (2006), N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor; J. Med. Chem., 49 6465 Green et al. (2009), Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530; Oncol., 3 248 de Wispelaere et al. (2013), The small molecules AZD0530 and Dasatinib inhibit dengue virus RNA replication via Fyn kinase; Virol., 87 7367 Shin et al. (2018), Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro; Viruses, 10 283 Tang et al. (2020), Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic mice and traumatic Tauopathy; Acta Neuropathol. Commun., 8 96 Kaufman et al. (2015), Fyn inhibition rescues established memory and synapse loss in Alzheimer mice; Neurol., 77 953
Saracatinib Preparation Products And Raw materials
Raw materials
Preparation Products
Saracatinib Suppliers
Global(196)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
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    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
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    BOC Sciences
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  • Email：inquiry@bocsci.com
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    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
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    AFINE CHEMICALS LIMITED
  • Tel：+86-0571-85134551
  • Email：sales@afinechem.com
  • Country：China
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Saracatinib Spectrum
379231-04-6, SaracatinibRelated Search:
  • Inhibitors
  • APIs
  • Protein Kinase Inhibitors and Activators
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  • Intermediates & Fine Chemicals
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  • 小分子抑制剂，天然产物
  • 科研试剂
  • C27H32ClN5O5
  • SARACATINIB(AZD0530,AZD-0530) |CAS 379231-04-6
  • ADZ-0530;AZ-0530;AZ-10353926;AZD-0530;AZD-O530;NSC-735464
  • 塞卡替尼,10 MM DMSO 溶液
  • N-(5-氯苯并[D][1,3]二氧杂环戊烯-4-基)-7-(2-(4-甲基哌嗪-1-基)乙氧基)-5-((四氢-2H-吡喃-4-氧基))喹唑啉-4-胺
  • 塞卡替尼AZD0530
  • N-(5-氯苯并[D][1,3]二氧戊环-4-基)-7-(2-(4-甲基哌嗪-1-基)乙氧基)-5-((四氢-2H-吡喃-4-基)氧基)喹唑啉-4-胺
  • SRC抑制剂(SARACATINIB)
  • N-(5-氯-1,3-苯并二氧戊环-4-基)-7-[2-(4-甲基-1-哌嗪基)乙氧基]-5-[(四氢-2H-吡喃-4-基)氧基]-4-喹唑啉胺
  • 379231-04-6
  • NSC-735464
  • AZD-O530
  • AZ-10353926
  • AZ-0530
  • ADZ-0530
  • Saracatinib, 10 mM in DMSO
  • N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine
  • Saracatinib AZD0530 AZD-0530
  • TIANFUCHEM-- Saracatinib
  • Saracatinib USP/EP/BP
  • EOS-61866
  • AZD0530; AZD-0530; AZD 0530
  • CS-69
  • N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyr
  • AZD0530 difuMarate
  • AZD0530(Saracatinib)
  • Saracatinib (AZD0530)
  • N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine
  • N-(5-Chloro-1,3-benzodioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine
  • 4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-(2-(4-methyl-1-piperazinyl)ethoxy)-5-((tetrahydro-2H-pyran-4-yl)oxy)-
  • 4-(6-Chloro-2,3-methylenedioxyanilino)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-tetrahydropyran-4-yloxyquinazoline
  • N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
  • saracatinib
  • Gemcabene Calcium
  • Saracatinib, >=98%
  • Saracatinib N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
  • N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine Saracatinib (AZD0530)
  • (S)-2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetaMide
  • 7-[2-[4-Methylpiperazin-1-yl]ethoxy]-5-[[tetrahydropyran-4-yl]oxy]-4-[[6-chloro-2,3-Methylenedioxyphenyl]aMino]quinazoline

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