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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Structure
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
  • CAS No.6318-41-8
  • Chemical Name:2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
  • CBNumber:CB13232856
  • Molecular Formula:C11H7NO4S
  • Formula Weight:249.24
  • MOL File:6318-41-8.mol
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Property
  • Density 1.595±0.06 g/cm3(Predicted)
  • storage temp. +2C to +8C
  • solubility Soluble in DMSO (up to 25 mg/ml).
  • form Yellow solid
  • pka 7.13±0.20(Predicted)
  • color Yellow
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
  • UNSPSC Code 12352200
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: 528114
  • Product name : PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem
  • Purity: The PI 3-Kγ Inhibitor VII, also referenced under CAS 6318-41-8, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primaril
  • Packaging: 5MG
  • Price: ₹15469.99
  • Updated: 2022/06/14
  • Buy: Buy

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Chemical Properties,Usage,Production

  • Description The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM), compared to PI3Kα (IC50 = 240 nM), PI3Kβ (IC50 = 1.45 μM), and PI3Kδ (IC50 =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.
  • Uses AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects[1].
  • in vivo

    AS-041164 (10-100 mg/kg; oral administration; once) treatment results in the reduction of inflammatory swelling in the model of carrageenan-induced paw edema[1].
    AS-041164 (3-100 mg/kg p.o.) treatment dose-dependently decreases r-h regulated on activation normal T cell expressed and secreted (RANTES)-induced neutrophil recruitment in mice. The ED50 value for AS-041164 is 27.35 mg/kg. AS-041164 blocks RANTES-induced chemotaxis and reduces the level of AKT phosphorylation[1].

    Animal Model:Male Wistar rats (100-150 g) injected with carrageenan[1]
    Dosage:10 mg/kg, 30 mg/kg, 100 mg/kg
    Administration:Oral administration; once
    Result:Induced a significant reduction of paw thickness.
  • IC 50 PI3Kγ: 70 nM (IC50); PI3Kα: 240 nM (IC50); PI3Kβ: 1.4 μM (IC50); PI3Kδ: 1.7 μM (IC50)
  • References 1) Ferrandi et al. (2007) Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment: J. Pharmacol. Exp. Ther. 322 923
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Preparation Products And Raw materials
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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Suppliers
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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Spectrum
6318-41-8, 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-Related Search:
  • 抑制剂
  • 化合物AS-041164,10 MM DMSO 溶液
  • AS-041164,PI3K GAMMA抑制剂
  • 5-(苯并[D][1,3]二氧戊环-5-基亚甲基)噻唑烷-2,4-二酮
  • 化合物AS-041164
  • 6318-41-8
  • PI 3-Kγ Inhibitor VII
  • PI 3-Kγ Inhibitor VII
  • AS-041164, 10 mM in DMSO
  • AS-041164, PI3K gamma inhibitor
  • 5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione
  • Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K
  • PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem
  • 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

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