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ROLIPRAM

ROLIPRAM Structure
ROLIPRAM
  • CAS No.61413-54-5
  • Chemical Name:ROLIPRAM
  • CBNumber:CB2703866
  • Molecular Formula:C16H21NO3
  • Formula Weight:275.34
  • MOL File:61413-54-5.mol
ROLIPRAM Property
  • Melting point 127-133 °C
  • Boiling point 418.29°C (rough estimate)
  • Density 1.0677 (rough estimate)
  • refractive index 1.5500 (estimate)
  • storage temp. Sealed in dry,Store in freezer, under -20°C
  • solubility H2O: 0.2 mg/mL
  • form solid
  • pka 16.02±0.40(Predicted)
  • color white to off-white
  • biological source synthetic (organic)
  • Water Solubility H2O: 0.2mg/mL
    ethanol: 7mg/mL
    DMSO: 7.3mg/mL
  • Merck 14,8251
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
  • FDA UNII K676NL63N7
  • UNSPSC Code 41106305
  • NACRES NA.77
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38-11
  • Safety Statements  :26-36
  • RIDADR  :3249
  • WGK Germany  :3
  • RTECS  :UY5749237
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :29337900
  • Toxicity :LD50 oral in mouse: > 300mg/kg
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a
ROLIPRAM Price More Price(6)
  • Brand: Sigma-Aldrich(India)
  • Product number: R6520
  • Product name : Rolipram
  • Purity: solid, ≥98% (HPLC)
  • Packaging: 10MG
  • Price: ₹21465.98
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: R6520
  • Product name : Rolipram
  • Purity: solid, ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹38017.4
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: R6520
  • Product name : Rolipram
  • Purity: solid, ≥98% (HPLC)
  • Packaging: 100MG
  • Price: ₹124303.48
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 557330
  • Product name : Rolipram - CAS 61413-54-5 - Calbiochem
  • Purity: A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC?? = 800 nM).
  • Packaging: 5MG
  • Price: ₹19050
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: R0110
  • Product name : Rolipram
  • Purity: 
  • Packaging: 50MG
  • Price: ₹10600
  • Updated: 2022/05/26
  • Buy: Buy

ROLIPRAM Chemical Properties,Usage,Production

  • Description Rolipram (61413-54-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 1 μM. Displays beneficial effects in neurodegenerative diseases. Rolipram also displays anti-inflammatory activity and synergizes with forskolin (cat.# 10-2073). Cell permeable.
  • Chemical Properties Yellowish solid
  • Uses (±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor.
  • Uses Pharmacological tool for characterization of phosphodiesterase isoenzymes.
  • Uses A selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4).
  • Uses antipsychotic
  • Definition ChEBI: Rolipram is a member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor. It has a role as an antidepressant and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.
  • General Description A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-κB and NFAT activation in Jurkat and primary T cells.
  • Biological Activity Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC 50 = 2.0 μ M). Discriminates between two conformational states of PDE4 isoenzymes. See separate isomers ((R)-(-)-Rolipram and (S)-(+)-Rolipram).
  • Biochem/physiol Actions Cell permeable: yes
  • storage Room temperature
  • References 1) Reeves et al. (1987), The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase; Biochem. J., 241 535 2) Nishi et al. (2008), Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum; J. Neurosci., 28 10460 3) Christiansen et al. (2011), Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP; Neurochem. Int., 59 837
ROLIPRAM Preparation Products And Raw materials
Raw materials
Preparation Products
ROLIPRAM Suppliers
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ROLIPRAM Spectrum
61413-54-5, ROLIPRAMRelated Search:
  • Signalling
  • Cyclic Nucleotide related
  • Antineoplastic
  • Inhibitors
  • DIPIPERON
  • Inhibitor
  • 抑制剂
  • 生化试剂
  • 药靶配体
  • 标准品
  • 代谢
  • 医药原料
  • 小分子抑制剂，天然产物
  • 杂环化合物
  • Phosphodiesterase Inhibitors
  • G Proteins and Cyclic Nucleotides
  • Cyclic Nucleotide Metabolism
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • C16H21NO3
  • 咯利普兰,10 MM DMSO 溶液
  • (R,S)-ROLIPRAM,SELECTIVE PDE4抑制剂
  • 罗利普兰
  • 4-[3-(环戊氧基)-4-甲氧基苯基]吡咯-2-酮
  • 诺普利兰, 一种PDE4抑制剂
  • ROLIPRAM 咯利普兰
  • 咯利普兰(消旋)
  • 诺普利兰
  • 咯利普兰
  • 61413-54-5
  • (±)-Rolipram
  • Rolipram, 10 mM in DMSO
  • (R,S)-Rolipram, Selective PDE4 inhibitor
  • (¨¤)-Rolipr
  • Rolipram (ZK-62711)
  • 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE
  • RolipramQ: What is Rolipram Q: What is the CAS Number of Rolipram Q: What is the storage condition of Rolipram Q: What are the applications of Rolipram
  • Rolipram (ME 3167
  • Rolipram - CAS 61413-54-5
  • ROLIPRAM USP/EP/BP
  • Rolipram Rolipram
  • Rolipram &gt
  • Rolipram, 98%, a PDE4 inhibitor
  • Rolipram - CAS 61413-54-5 - Calbiochem
  • SB95952;ZK62711;(R;S)-ROLIPRAM;SB 95952;ZK 62711;SB-95952;ZK-62711
  • 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinon
  • ZK-62711
  • PYRROLIDIN-2-ONE, 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)- (+/-)
  • ROLIPRAM
  • Rolipram, >=97%
  • ZK-62711, SB95952, ME-3167
  • (R,S)-Rolipram
  • 4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]-2-PYRROLIDINONE
  • 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK62711
  • SB 95952
  • 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
  • Roliprame

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