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GW441756

GW441756 Structure
GW441756
  • CAS No.504433-23-2
  • Chemical Name:GW441756
  • CBNumber:CB1839809
  • Molecular Formula:C17H13N3O
  • Formula Weight:275.3
  • MOL File:504433-23-2.mol
GW441756 Property
  • Boiling point 568.0±50.0 °C(Predicted)
  • Density 1.31±0.1 g/cm3(Predicted)
  • storage temp. Store at RT
  • solubility Soluble in DMSO (up to 5 mg/ml).
  • pka 11.04±0.20(Predicted)
  • form solid
  • color Orange
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

GW441756 Chemical Properties,Usage,Production

  • Description GW-441756 (504433-23-2) is a potent and selective TrkA kinase inhibitor (IC50 = 2 nM).
  • Uses GW 441756 is an effective Trk binder, a novel bioactive molecule used in the treatment of neuroblastoma in infants.
  • Definition ChEBI: 3-[(1-methyl-3-indolyl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one is a member of indoles.
  • Biological Activity Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC 50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.
  • storage Store at RT
  • References 1) Wood et al. (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg. Med. Chem. Lett. 14 953 2) Takemoto et al. (2015) Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury; Environ. Toxicol. Pharmacol. 40 199 [Focus Citation]
GW441756 Preparation Products And Raw materials
Raw materials
Preparation Products
GW441756 Suppliers
Global(142)Suppliers
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29859
  • Advantage：58
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
GW441756 Spectrum
504433-23-2, GW441756Related Search:
  • Inhibitors
  • Angiogenesis and Metastasis
  • 药靶配体
  • 抑制剂
  • 细胞生物学试剂
  • 小分子抑制剂，天然产物
  • 蛋白酪氨酸激酶
  • 504433-23-3
  • 化合物GW 441756,10 MM DMSO 溶液
  • GW-441756 HYDROCHLORIDE,TRKA RECEPTOR TYROSINE KINASE抑制剂
  • GW441756,TRKA受体酪氨酸激酶抑制剂
  • TRKA抑制剂(GW 441756)
  • 1,3-二氢-3-[(1-甲基-1H-吲哚-3-基)亚甲基]-2H-吡咯并[3,2-B]吡啶-2-酮
  • 504433-23-2
  • GW 441756, 10 mM in DMSO
  • GW 441756/GW 441758
  • GW-441756 hydrochloride, TrKA receptor tyrosine kinase inhibitor
  • GW441758
  • 3-((1-methyl-1H-indol-3-yl)methylene)-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one
  • GW441756 USP/EP/BP
  • W 441756
  • GW441756, >98%
  • CS-1085
  • GW 441756; GW-441756
  • 3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-1H-PYRROLO[3,2-B]PYRIDIN-2-ONE;HYDROCHLORIDE
  • 3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one
  • -3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
  • (Z)-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
  • 2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-
  • Gw
  • GW 441756
  • 1,3-DIHYDRO-3-[(1-METHYL-1H-INDOL-3-YL)METHYLENE]-2H-PYRROLO[3,2-B]PYRIDIN-2-ONE

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