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Raltitrexed

Raltitrexed Structure
Raltitrexed
  • CAS No.112887-68-0
  • Chemical Name:Raltitrexed
  • CBNumber:CB1222070
  • Molecular Formula:C21H22N4O6S
  • Formula Weight:458.49
  • MOL File:112887-68-0.mol
Raltitrexed Property
  • Melting point 176-1800C
  • Density 1.49±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility H2O: ≥10mg/mL
  • pka 3.50±0.10(Predicted)
  • form solid
  • color off-white to light yellow
  • Water Solubility H2O: ≥10mg/mL
    DMSO: ≥40mg/mL
  • InChIKey IVTVGDXNLFLDRM-HNNXBMFYSA-N
  • CAS DataBase Reference 112887-68-0(CAS DataBase Reference)
  • NCI Dictionary of Cancer Terms ICI D1694; raltitrexed
  • FDA UNII FCB9EGG971
  • NCI Drug Dictionary raltitrexed
  • ATC code L01BA03
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300-H360
  • Precautionary statements P201-P301+P310+P330
Raltitrexed Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: R9156
  • Product name : Raltitrexed
  • Purity: ≥98% (HPLC), solid
  • Packaging: 10MG
  • Price: ₹14473.03
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: R9156
  • Product name : Raltitrexed
  • Purity: ≥98% (HPLC), solid
  • Packaging: 50MG
  • Price: ₹58357.58
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: R0208
  • Product name : Raltitrexed
  • Purity: 
  • Packaging: 50MG
  • Price: ₹6500
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: R0208
  • Product name : Raltitrexed
  • Purity: 
  • Packaging: 250MG
  • Price: ₹17200
  • Updated: 2022/05/26
  • Buy: Buy

Raltitrexed Chemical Properties,Usage,Production

  • Description Tomudex was launched in Ireland, France, Luxembourg and the UK for advanced colorectal cancer and it was prepared in a convergent manner (6 steps) from diethyl L-glutamate and 6-bromomethyi-2-methyl-quinazolin4(3H)-one. Tomudex is a highly selective inhibitor of thymidylate synthase (TS), the key enzyme in the biochemical conversion of dUMP to dTMP. It enters the cell via the reduced folatefmethotrexate cell membrane carrier and is converted to the polyglutamate species by folylpolyglutamate synthase within 4h where it then binds to the folate substrate site of TS. Clinically, it had a 29% response rate in patients with advanced colorectal cancer. It is water soluble, can be administered as a single dose every three weeks and had no hepto- or nephrotoxicity.
  • Chemical Properties Yellow Crystalline Powder
  • Originator Zeneca (UK)
  • Uses Folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives. Antineoplastic
  • Definition ChEBI: ICI D1694 is a N-acyl-amino acid.
  • brand name Tomudex (Zeneca).
  • Biochem/physiol Actions Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.
  • Clinical Use Treatment of colorectal cancer when fluorouracil and folinic acid cannot be used
  • Drug interactions Potentially hazardous interactions with other drugs
    Antipsychotics: avoid with clozapine, increased risk of agranulocytosis.
    Folic and folinic acid: impairs cytotoxic action - avoid.
  • Metabolism Raltitrexed is actively transported into cells and metabolised to active polyglutamate forms.
    The remainder of a dose is not metabolised and is excreted unchanged, about 50% of a dose appearing in the urine, and about 15% in the faeces.
Raltitrexed Preparation Products And Raw materials
Raw materials
Preparation Products
Raltitrexed Suppliers
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Raltitrexed Spectrum
112887-68-0, RaltitrexedRelated Search:
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  • 化学试剂-精细化工
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  • 小分子抑制剂，天然产物
  • 药物
  • DNA损伤
  • 抗肿瘤类药物及免疫抑制剂
  • C21H22N4O6SxH2O
  • C21H22N4O6S
  • 112887-68-7
  • 12887-68-0
  • 雷替曲塞,10 MM DMSO 溶液
  • HREF="HTTP://WWW.UNITECHEMICAL.COM/PRODUCT_LIST/ID/137.HTML" 雷替曲噻
  • (S)-2-(5-(甲基((2-甲基-4-氧代-1,4-二氢喹唑啉-6-基)甲基)氨基)噻吩-2-甲酰胺基)戊二酸
  • 雷替曲塞单水合物
  • 雷替曲塞
  • 兰替特噻
  • N-[[5-[[(1,4-二氢-2-甲基-4-氧-6-喹唑啉基)甲基]甲氨基]-2-噻吩基]羰基]-L-谷氨酸
  • 雷替曲塞/N-[[5-[[(1,4-二氢-2-甲基-4-氧-6-喹唑啉基)甲基]甲氨基]-2-噻吩基]羰基]-L-谷氨酸
  • 112887-68-0
  • Raltitrexed, 10 mM in DMSO
  • TDX
  • Retitrose
  • Raltitrexe
  • Tomudex
  • (S)-2-(5-(Methyl((2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)amino)thiophene-2-carboxamido)pentanedioic acid
  • Raltitrexed USP/EP/BP
  • Raltitrexed (ZD1694
  • D1694
  • (2s)-2-[[5-[methyl-[(2-methyl-4-oxo-1h-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic Acid
  • CS-664
  • Raltitrexed, >=99%
  • Raltitrexed monohydrate
  • L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl)- monohydrate
  • N-[[5-[[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]- L-glutamic acid
  • (S)-2-(5-(Methyl((2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)-methyl)amino)thiophene-2-carboxam
  • Raltirexed
  • Raltitrexed(ToMudex)
  • ZEN-D-1694

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