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1400W

1400W Structure
1400W
  • CAS No.180001-34-7
  • Chemical Name:1400W
  • CBNumber:CB5343313
  • Molecular Formula:C10H15N3
  • Formula Weight:177.25
  • MOL File:180001-34-7.mol
1400W Property
  • Melting point 208-220 °C
  • Boiling point 301.7±44.0 °C(Predicted)
  • Density 1.09±0.1 g/cm3(Predicted)
  • storage temp. −20°C
  • solubility DMSO, Methanol, Water
  • pka 11.33±0.50(Predicted)
  • form solid
  • color White to Off-White
  • FDA UNII M1VB8VP8OH
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

1400W Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Uses A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM
  • Uses 1400W selectively inhibits inducible nitric oxide synthase. W 1400 has been implicated to prevent Doxorubicin and Trastuzumab induced cardiotoxicity.
  • Definition ChEBI: N-[3-(aminomethyl)benzyl]acetamidine is an aralkylamine that is Nbenzylacetamidine substituted at position 3 on the benzene ring by an aminomethyl group. An inhibitor of nitric oxide synthase. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor, a geroprotector and an angiogenesis inhibitor. It is a carboxamidine, an aralkylamine and a primary amino compound.
  • Biological Activity Slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (K d = 7 nM). Selective over nNOS and eNOS (K i values are 2 and 50 μ M respectively). Cell-permeable and active in vivo .
  • in vivo

    1400W (0.1-10 mg/kg, s.c., once time) inhibits the leakage of rats ileum, with an EC50 of 0.16 mg/kg[1].

1400W Preparation Products And Raw materials
Raw materials
Preparation Products
1400W Suppliers
Global(67)Suppliers
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1400W Spectrum
180001-34-7, 1400WRelated Search:
  • Signalling
  • Aromatic Building Blocks
  • Nitric Oxide
  • Nitric Oxide Reagents
  • 细胞生物学试剂
  • Nitric Oxide Metabolism
  • Enzymes, Inhibitors, and Substrates
  • NOS Inhibitors
  • Cell Signaling Enzymes
  • Application Index
  • BioChemical
  • Biochemicals and Reagents
  • 18001-34-7
  • W 1400
  • NO SYNTHASE抑制剂(1400W DIHYDROCHLORIDE)
  • N-[3-(氨甲基)苄基]乙脒
  • 180001-34-7
  • N-(3-(aminomethyl)benzyl)acetimidamide
  • 1400W DIHYDROCHLORIDE
  • Ethanimidamide, N-[[3-(aminomethyl)phenyl]methyl]-
  • W 1400
  • 400W
  • N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE, DIHYDROCHLORIDE
  • N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE 2HCL
  • N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE
  • N-[[3-(AMINOMETHYL)PHENYL]METHYL]-ETHANIMIDAMIDE DIHYDROCHLORIDE
  • 1400W

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