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Sevelamer carbonate

Sevelamer carbonate Structure
Sevelamer carbonate
  • CAS No.845273-93-0
  • Chemical Name:Sevelamer carbonate
  • CBNumber:CB32128754
  • Molecular Formula:C7H14ClNO4
  • Formula Weight:211.64
  • MOL File:845273-93-0.mol
Sevelamer carbonate Property
  • storage temp. Room Temperature, under inert atmosphere
  • solubility <4.74mg/mL in DMSO
  • form Solid
  • color White to Pale Beige
  • InChI InChI=1S/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4)
  • InChIKey PADGNZFOVSZIKZ-UHFFFAOYSA-N
  • SMILES C(O)(O)=O.C(C1OC1)Cl.C(=C)CN
  • FDA UNII 9YCX42I8IU
  • UNSPSC Code 41116107
  • NACRES NA.24
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements H412
  • Precautionary statements P273-P501

Sevelamer carbonate Chemical Properties,Usage,Production

  • Description Sevelamer carbonate (SC) is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. SC has been found to have the same safety and efficacy profile as Sevelamer HCl in HD patients.
    Sevelamer carbonate(Renvela) is a nonaluminum, non-calcium-basedphosphorus binder that traps phosphorus in the bowel through ion exchange and hydrogen binding. This drug replaced sevelamer hydrochloride(Renagel) and has an advantage of not generating an acid load, as its precursor, sevelamer hydrochloride, did. It also has the advantage of lowering LDL cholesterol due to gut binding of bile acids.
  • Uses Control of serum phosphorus in patients with chronic kidney disease (phosphate binder).
  • Uses Sevelamer Carbonate, a non-?absorbed polymer is an oral phosphate binder in patients with kidney failure. It is reported that Sevelamer Carbonate is less likely to cause hypercalcemia, low levels of PTH, and progressive coronary and aortic calcification in hemodialysis patients than calcium-?based phosphate binders.
  • Side effects The Common Side Effects of Sevelamer carbonate:
    Vomiting (22%), Nausea (20%), Diarrhea (19%), Indigestion (16%), Stomach pain (9%), Feeling gassy (8%), and Constipation (8%).
    The Serious Side Effects of Sevelamer carbonate:
    Stomach or intestine problems: bowel blockage, bleeding ulcers, severe stomach pain, blood in your stool.
  • Mode of action The active substance in Sevelamer carbonate Winthrop, sevelamer carbonate, is a phosphate binder. When taken with meals, it attaches in the gut to phosphate from the food, thereby preventing the phosphate from being absorbed into the body and helping to reduce phosphate levels in the blood.
Sevelamer carbonate Preparation Products And Raw materials
Raw materials
Preparation Products
Sevelamer carbonate Suppliers
Global(211)Suppliers
  • Supplier：
    Protheragen-ING
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    Xiamen AmoyChem Co., Ltd
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  • Country：China
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Sevelamer carbonate Spectrum
845273-93-0, Sevelamer carbonateRelated Search:
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  • 845273-93-0
  • SEVELEMER CARBONATE
  • Sevelam carbonate
  • 2-Propen-1-amine polymer with (chloromethyl)oxirane carbonate ISO 9001：2015 REACH
  • Sevelamer Carbonate, Technical Grade
  • SIM862 Sevelamer Carbonate-----25gm
  • carbonic acid,2-(chloromethyl)oxirane,prop-2-en-1-amine
  • 2-Propen-1-aminepolymerwith
  • 2-Propen-1-amine polymer with (chloromethyl)oxiran
  • Sevelam
  • Carbonic acid, compd. with 2-(chloromethyl)oxirane polymer with 2-propen-1-amine
  • Sevelamer carbonate
  • 2-Propen-1-amine polymer with (chloromethyl)oxirane carbonate

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