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Sevelamer

Sevelamer Structure
Sevelamer
  • CAS No.52757-95-6
  • Chemical Name:Sevelamer
  • CBNumber:CB91106827
  • Molecular Formula:C6H12ClNO
  • Formula Weight:149.62
  • MOL File:52757-95-6.mol
Sevelamer Property
  • storage temp. Store at -20°C
  • solubility Soluble in DMSO
  • FDA UNII 941N5DUU5C
  • ATC code V03AE02
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Sevelamer Chemical Properties,Usage,Production

  • Uses Antihyper-phosphatemic.
  • brand name Renagel (Genzyme).
  • Pharmaceutical Applications In patients on dialysis, Sevelamer or lanthanum salts can be used to maintain normal phosphate blood levels. Sevelamer is a polymer containing amine groups. These protonated amine groups can react with the negatively charged phosphate groups via ionic binding and prevent absorption of phosphate from the gut. Sevelamer is a hydrogel containing cross-linked polyallylamine chains. The negatively charged phosphate can be bound to the positively charged amine groups of the hydrogel in the intestines and removed via the faeces.
  • Clinical Use Phosphate-binding agent
  • Drug interactions Potentially hazardous interactions with other drugs
    Antibacterials: reduces bioavailability of ciprofloxacin.
    Ciclosporin: possibly reduces ciclosporin
    concentration.
    Calcitriol: absorption may be impaired by sevelamer.
    Mycophenolate: may reduce mycophenolate levels.
    Tacrolimus: possibly reduces tacrolimus
    concentration.
    Thyroid hormones: possibly reduces levothyroxine
    concentration.
  • Metabolism Sevelamer is not systemically absorbed.
Sevelamer Preparation Products And Raw materials
Raw materials
Preparation Products
Sevelamer Suppliers
Global(27)Suppliers
  • Supplier：
    AFINE CHEMICALS LIMITED
  • Tel：+86-0571-85134551
  • Email：sales@afinechem.com
  • Country：China
  • ProdList：15417
  • Advantage：58
  • Supplier：
    GIHI CHEMICALS CO.,LIMITED
  • Tel： +8618058761490
  • Email：info@gihichemicals.com
  • Country：China
  • ProdList：49984
  • Advantage：58
  • Supplier：
    LEAPCHEM CO., LTD.
  • Tel：+86-852-30606658
  • Email：market18@leapchem.com
  • Country：China
  • ProdList：43340
  • Advantage：58
  • Supplier： Gihi Chemicals Co., Limited
  • Tel：+86-0571-86217390<br/>+8618058761490
  • Email：info@gihichem.com
  • Country：China
  • ProdList：998
  • Advantage：58
  • Supplier： Cantotech Chemicals, Ltd.
  • Tel：86-0755-86635001
  • Email：cantotech@126.com
  • Country：China
  • ProdList：4566
  • Advantage：55
  • Supplier： Musechem
  • Tel：+1-800-259-7612
  • Email：info@musechem.com
  • Country：United States
  • ProdList：4660
  • Advantage：60
  • Supplier： DC Chemicals
  • Tel：021-58447131<br/>13564518121
  • Email：sales@dcchemicals.com
  • Country：China
  • ProdList：9409
  • Advantage：58
Sevelamer Spectrum
  • 医药原料药
  • C3H7NxC3H5ClOx
  • 烯丙胺-环氧氯丙烷共聚物
  • 52757-95-6
  • Epichlorohydrin-PAA 25 copolymer
  • Sevelamer [inn:ban]
  • Oxirane, (chloromethyl)-, polymer with 2-propen-1-amine
  • Hsdb 7608
  • Allylamine-epichlorohydrin copolymer
  • Allylamine polymer with 1-chloro-2,3-epoxypropane
  • 2-Propen-1-amine, polymer with (chloromethyl)oxirane
  • Sevelamer

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