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Bis-Mal-Lysine-PEG4-TFP ester

Bis-Mal-Lysine-PEG4-TFP ester Structure
Bis-Mal-Lysine-PEG4-TFP ester
  • CAS No.1426164-53-5
  • Chemical Name:Bis-Mal-Lysine-PEG4-TFP ester
  • CBNumber:CB23062405
  • Molecular Formula:C37H45F4N5O13
  • Formula Weight:843.77
  • MOL File:1426164-53-5.mol
Bis-Mal-Lysine-PEG4-TFP ester Property
  • Boiling point 1012.1±65.0 °C(Predicted)
  • Density 1.364±0.06 g/cm3(Predicted)
  • pka 14.12±0.46(Predicted)
  • form Solid
  • color White to off-white
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Bis-Mal-Lysine-PEG4-TFP ester Chemical Properties,Usage,Production

  • Description Bis-Mal-Lysine-PEG4-TFP ester contains two malimide end groups which can react with thiol groups from pH 6.5 to 7.5 to form thiolester bonds. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG linker increases the compound's water solubility in aqueous environments.
  • Uses Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • IC 50 PEGs
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Bis-Mal-Lysine-PEG4-TFP ester Preparation Products And Raw materials
Raw materials
Preparation Products
Bis-Mal-Lysine-PEG4-TFP ester Suppliers
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Bis-Mal-Lysine-PEG4-TFP ester Spectrum
1426164-53-5, Bis-Mal-Lysine-PEG4-TFP esterRelated Search:
  • 化学试剂
  • PEG系列产品-Bis-PEG系列
  • C37H45F4N5O13
  • 双-马来酰亚胺-赖氨酸-四聚乙二醇-TFP酯
  • 双马来酰亚胺-赖氨酸-PEG4-琥珀酰亚胺酯
  • 双马来酰亚胺-赖氨酸-四聚乙二醇-四氟苯酚酯
  • 双马来酰亚胺-赖氨酸-四聚乙二醇-TFP
  • 双马来酰亚胺-赖氨酸-四聚乙二醇-琥珀酰亚胺酯
  • 1426164-53-5
  • Bis-MAL-Lysine-dPEG??-TFP ester (QBD-10631)
  • 4,7,10,13-Tetraoxa-16,23-diazahexacosanoic acid, 26-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-18-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]-17,24-dioxo-, 2,3,5,6-tetrafluorophenyl ester, (18S)-
  • Bis-Mal-Lysine-PEG4-TFP ester

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