ChemicalBook > CAS DataBase List > Mal-PEG2-amine
Mal-PEG2-amine
Mal-PEG2-amine
- CAS No.660843-22-1
- Chemical Name:Mal-PEG2-amine
- CBNumber:CB73162984
- Molecular Formula:C10H16N2O4
- Formula Weight:228.24
- MOL File:660843-22-1.mol
Mal-PEG2-amine Property
- Boiling point 379.9±27.0 °C(Predicted)
- Density 1.226±0.06 g/cm3(Predicted)
- solubility Soluble in Water, DMSO, DCM, DMF
- pka 8.74±0.10(Predicted)
- Symbol(GHS)
- Signal word
- Hazard statements
- Precautionary statements
Mal-PEG2-amine Chemical Properties,Usage,Production
- Description Mal-PEG2-amine TFA salt is a PEG linker containing a maleimide group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
- Uses Mal-PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
- IC 50 PEGs
- References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Mal-PEG2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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660843-22-1, Mal-PEG2-amineRelated Search:
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- 660843-22-1
- 1-{2-[2-(2-aminoethoxy)ethoxy]ethyl}-2,5-dihydro-1H-pyrrole-2,5-dione
- Mal-PEG2-NH2
- 1H-?Pyrrole-?2,?5-?dione, 1-?[2-?[2-?(2-?aminoethoxy)?ethoxy]?ethyl]?-
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- Mal-PEG2-amine TFA salt
- Mal-PEG2-amine