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TETRODOTOXIN CITRATE

TETRODOTOXIN CITRATE Structure
TETRODOTOXIN CITRATE
  • CAS No.18660-81-6
  • Chemical Name:TETRODOTOXIN CITRATE
  • CBNumber:CB2192024
  • Molecular Formula:C17H25N3O15
  • Formula Weight:511.39
  • MOL File:18660-81-6.mol
TETRODOTOXIN CITRATE Property
  • storage temp. Desiccate at -20°C
  • solubility Citrate Buffer (pH 4.8): 30 mg/ml (100 mM)
  • form A solid
  • pka 8.76(at 25℃)
  • Water Solubility Soluble to 100 mM in water
  • Stability Unstable in Acidic solution, Unstable In Acidic Solution
  • FDA UNII 3KUM2721U9
  • NCI Drug Dictionary tetrodotoxin
Safety
  • Hazard Codes  :T+
  • Risk Statements  :26/27/28
  • Safety Statements  :22-36/37/39-45
  • RTECS  :IO1450000
  • Toxicity :A toxin contained in the ovary and liver of puffer fish, in the eggs of the California newt and in some other animals. It is used as a chemical tool for the study of ion channels. The s.c. LD50 in mice is 10 mg/kg. It is a toxicant of nerve and muscle by blocking sodium channels, this action causing nerve and muscle paralysis. Symptoms include weakening of voluntary muscles, respiratory failure from paralysis of the diaphragm and hypotension. There is no antidote. Therapy involves artificial respiration.
  • NFPA 704:
    0
    4 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300-H330-H310
  • Precautionary statements P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501

TETRODOTOXIN CITRATE Chemical Properties,Usage,Production

  • Description TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (Nav) channels, blocking nerve and muscle action potentials. It inhibits the Nav current in frog muscle and squid axon with IC50 values of 4.1 and 5.2 nM, respectively, and binds to rat brain membranes with a Kd value of 1.8 nM. TTX was used in Hodgkin and Huxley’s classic experiments to elucidate the physical biology of nerve action potentials and remains an indispensible neuroscience tool to pharmacologically dissect the contribution of the Nav current in excitable neurons and to rationally design compounds for the treatment of neuropathic pain. This citrate-stabilized form of TTX is designed for improved solubility over pure TTX , which is insoluble in water and most organic solvents. This preparation of TTX citrate consists of TTX that has been dissolved in a citrate solution and then lyophilized.
  • Uses Tetrodotoxin Citrate is a highly selective, reversible sodium channel blocker.
  • Biological Activity Highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin.
  • storage Store at -20°C
TETRODOTOXIN CITRATE Preparation Products And Raw materials
Raw materials
Preparation Products
TETRODOTOXIN CITRATE Suppliers
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TETRODOTOXIN CITRATE Spectrum
18660-81-6, TETRODOTOXIN CITRATERelated Search:
  • Sodium channel
  • C17H25N3O15
  • C11H17N3O8C6H8O7
  • 河豚毒素柠檬酸酯盐
  • 河豚毒素鹼
  • 18660-81-6
  • (5R,6R,7S,9R,11R,12R,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 2-hydroxypropane-1,2,3-tricarboxylate (1:1) (non-preferred name)
  • Tetrodotoxin(TTX), with citrate
  • Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci)
  • Citrato de tetrodotoxina [spanish]
  • Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat
  • tetrodotoxin,citrate(1:1)(salt)
  • citratodetetrodotoxina
  • OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE
  • TETRODOTOXIN CITRATE

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