Synthesis
Step 1, estradiol as raw material, and heptanoyl chloride in the pyridine catalyzed reaction to obtain diheptanoic acid estradiyl ester;
Step 2, the diheptanoic acid estradiyl ester in step 1 as raw material, in an alcohol solvent, under the action of alkali hydrolysis reaction, after post-treatment to obtain the estradiol heptanoic acid crude;
Step 3, the estradiol heptanoic acid crude in step 2 as the raw material, and methanol purification to obtain the estradiol heptanoate fine. Step 3, using the crude product of estradiol heptanoate in step 2 as raw material, the methanol refining was used to obtain the fine product of estradiol heptanoate.
Step 3
