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Estradiol benzoate

Estradiol benzoate Property

Melting point 191-198 °C(lit.)
alpha D25 +58 to +63° (c = 2 in dioxane)
Boiling point 465.03°C (rough estimate)
Density 1.0493 (rough estimate)
refractive index 1.5460 (estimate)
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in methylene chloride, sparingly soluble in acetone, slightly soluble in methanol.
form Solid
pka 15.06±0.40(Predicted)
color White
Water Solubility 0.4mg/L(25 ºC)
Merck 3703
BRN 3107526
CAS DataBase Reference 50-50-0(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 1S4CJB5ZGN
NIST Chemistry Reference Estradiol benzoate(50-50-0)
UNSPSC Code 41116107
NACRES NA.24

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Estradiol benzoate Chemical Properties,Usage,Production

Chemical Properties White solid
Uses antiacne, antineoplastic
Uses Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position. Estradiol benzoate is useful in the treatment of lesions produced by diminution of bodily production of estrogens.
Definition ChEBI: A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol.
Clinical Use Estradiol is a semisynthetic estrogen compound. Its effects will mimic that of estrogen in animals. The most common use in small animals has been to terminate pregnancy.
Estradiol benzoate also has been used to terminate pregnancy (5-10 mg/kg divided into two or three SQ injections). Estradiol cypionate formulation had high efficacy (95%), but it had serious adverse effects and is not recommended. Estradiol cypionate is longer acting and more potent than other estrogen formulations. Estradiol valerate injection (20 mg/mL) is also available for human medicine to treat hypoestrogenism.
Safety Profile Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human reproductive effects by intramuscular route: menstrual cycle changes and disorders. Experimental reproductive effects. Mutation data reported. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTRADIOL.

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Estradiol benzoate Spectrum

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原料药 > 激素及调节内分泌功能类药 > 雌激素及孕激素类药 > 苯甲酸雌二醇
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