Chemical Properties
yellow oil bp0.7 210-212°C soluble in alcohol, chloroform, essentially water insoluble anasthetic Epontol (Bayer) Sombrevin
Uses
Sombrevin, is an ultra short-acting phenylacetate general anesthetic.
Uses
Anesthetic (intravenous).
Definition
ChEBI: Propanidid is a member of methoxybenzenes.
brand name
Epontol (Farbenfabriken
Bayer A.G., Germany).
Clinical Use
Propanidid is used as a very short- to shortacting
intravenous anesthetic for minor surgery
and gynecology. It is characterized by rapid
onset of and quick recovery from anesthesia,
producing surgical anesthesia for 3 – 4 min. Repeated
injections can be used to prolong the
anesthesia. Postanesthetic sleep does not occur
because the propyl ester is hydrolyzed rapidly
in the patient to form inactive 3-methoxy-4-
(N,N-diethylcarbamoylmethoxy)phenylacetic
acid. After 20 – 30 min the patients generally
are completely responsive .
Synthesis
Propanidid , propyl 3-
methoxy-4-(N,N-diethylcarbamoylmethoxy)-
phenylacetate, is a colorless to pale
yellowish water-insoluble oil. It is prepared
from the propyl ester of sodium homovanillic
acid and N,N-diethylchloroacetamide .
