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L-Malic acid

CAS No.97-67-6
Chemical Name:L-Malic acid
CBNumber:CB0493594
Molecular Formula:C4H6O5
Formula Weight:134.09
MOL File:97-67-6.mol

L-Malic acid Property

Melting point 101-103 °C (lit.)
Boiling point 167.16°C (rough estimate)
alpha -2 º (c=8.5, H2O)
Density 1.60
bulk density 600kg/m3
vapor pressure 0Pa at 25℃
FEMA 2655 | L-MALIC ACID
refractive index -6.5 ° (C=10, Acetone)
Flash point 220 °C
storage temp. Store below +30°C.
solubility H₂O: 0.5 M at 20 °C, clear, colorless
form Powder
Specific Gravity 1.595 (20/4℃)
color White
PH 2.2 (10g/l, H2O, 20℃)
pka (1) 3.46, (2) 5.10(at 25℃)
Odor odorless
Odor Type odorless
biological source microbial
optical activity [α]20/D 30±2°, c = 5.5% in pyridine
Water Solubility soluble
JECFA Number 619
Merck 14,5707
BRN 1723541
InChIKey BJEPYKJPYRNKOW-REOHCLBHSA-N
LogP -1.68
Substances Added to Food (formerly EAFUS) L-MALIC ACID
SCOGS (Select Committee on GRAS Substances) L-Malic acid
CAS DataBase Reference 97-67-6(CAS DataBase Reference)
FDA UNII J3TZF807X5
NIST Chemistry Reference Butanedioic acid, hydroxy-, (s)-(97-67-6)
EPA Substance Registry System Butanedioic acid, 2-hydroxy-, (2S)- (97-67-6)
UNSPSC Code 51113400
NACRES NA.75

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36-37/39
WGK Germany :3
RTECS :ON7175000
TSCA :Yes
HS Code :29181980

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H319
Precautionary statements P264-P280-P305+P351+P338-P337+P313

L-Malic acid Price More Price(21)

Brand: Sigma-Aldrich(India)
Product number: M7397
Product name : L-(−)-Malic acid
Purity: suitable for cell culture, BioReagent, suitable for insect cell culture
Packaging: 25G
Price: ₹6419.23
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M7397
Product name : L-(−)-Malic acid
Purity: suitable for cell culture, BioReagent, suitable for insect cell culture
Packaging: 100G
Price: ₹14689.53
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M7397
Product name : L-(−)-Malic acid
Purity: suitable for cell culture, BioReagent, suitable for insect cell culture
Packaging: 500G
Price: ₹48485.18
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M6413
Product name : L-(−)-Malic acid
Purity: BioXtra, ≥95%
Packaging: 25G
Price: ₹5315.08
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M6413
Product name : L-(−)-Malic acid
Purity: BioXtra, ≥95%
Packaging: 100G
Price: ₹15165.83
Updated: 2022/06/14
Buy: Buy

L-Malic acid Chemical Properties,Usage,Production

Description L-Malic acid is nearly odorless (sometimes a faint, acrid odor) with a tart, acidic taste. It is nonpungent. May be prepared by hydration of maleic acid; by fermentation from sugars.
Chemical Properties L-Malic acid is nearly odorless (sometimes a faint, acrid odor). This compound has a tart, acidic, nonpungent taste.
Chemical Properties clear colourless solution
Occurrence Occurs in maple sap, apple, melon, papaya, beer, grape wine, cocoa, sake, kiwifruit and chicory root.
Uses The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid rece
Uses L-Malic acid is used as a food additive, Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, and phoslactomycin B.
Uses Intermediate in chemical synthesis. Chelating and buffering agent. Flavoring agent, flavor enhancer and acidulant in foods.
Preparation L-Malic acid can be prepared by hydration of maleic acid; by fermentation from sugar.
Definition ChEBI: An optically active form of malic acid having (S)-configuration.
General Description L-Malic acid is an organic acid that is commonly found in wine. It plays an important role in wine microbiological stability.
Biochem/physiol Actions L-Malic acid is a part of cellular metabolism. Its application is recognized in pharmaceutics. It is useful in the treatment of hepatic malfunctioning, effective against hyper-ammonemia. It is used as a part of amino acid infusion. L-Malic acid also serves as a nanomedicine in the treatment of brain neurological disorders. A TCA (Krebs cycle) intermediate and partner in the malic acid aspartate shuttle.
Purification Methods Crystallise S-malic acid (charcoal) from ethyl acetate/pet ether (b 55-56o), keeping the temperature below 65o. Or dissolve it by refluxing in fifteen parts of anhydrous diethyl ether, decant, concentrate to one-third volume and crystallise it at 0o, repeatedly to constant melting point. [Beilstein 3 IV 1123.]