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Calcium gluconate

Description References

Calcium gluconate

CAS No.299-28-5
Chemical Name:Calcium gluconate
CBNumber:CB0473578
Molecular Formula:C12H22CaO14
Formula Weight:430.37
MOL File:299-28-5.mol

Calcium gluconate Property

Melting point 195°C
alpha 10.2 º (c=1, H2O 22 ºC)
Boiling point 400℃[at 101 325 Pa]
Density 1.677[at 20℃]
vapor pressure 0.004Pa at 20℃
storage temp. Inert atmosphere,Room Temperature
solubility Sparingly soluble in water, freely soluble in boiling water.
form Crystals or Crystalline Powder
color White
PH pH;6.0～8.0
Odor at 100.00?%. odorless
biological source synthetic (organic)
Water Solubility 3.3 g/100mL
Hydrolytic Sensitivity 0: forms stable aqueous solutions
Merck 14,1669
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey KYUVBRZSDFBLTH-OSQBQZLYSA-M
LogP -5.31 at 20℃
CAS DataBase Reference 299-28-5(CAS DataBase Reference)
FDA 21 CFR 184.1199; 582.1199; 582.6199; 310.545
Substances Added to Food (formerly EAFUS) CALCIUM GLUCONATE
SCOGS (Select Committee on GRAS Substances) Calcium gluconate
EWG's Food Scores 1
NCI Dictionary of Cancer Terms calcium gluconate
FDA UNII SQE6VB453K
NCI Drug Dictionary calcium gluconate
ATC code A12AA03,D11AX03
EPA Substance Registry System D-Gluconic acid, calcium salt (2:1) (299-28-5)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xn
Risk Statements :20/21/22-36/37/38
Safety Statements :24/25-36-26
WGK Germany :1
RTECS :EW2100000
TSCA :No
HS Code :29181600
Hazardous Substances Data :299-28-5(Hazardous Substances Data)
Toxicity :dog,LDLo,intravenous,1987mg/kg (1987mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 47, Pg. 183, 1933.

NFPA 704:

	1
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319
Precautionary statements P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Calcium gluconate Price More Price(8)

Brand: Sigma-Aldrich(India)
Product number: C8231
Product name : Calcium D-gluconate
Purity: anhydrous, meets USP testing specifications (Not intended for use in preparing injectable dosage forms.)
Packaging: 100G
Price: ₹4773.83
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: C8231
Product name : Calcium D-gluconate
Purity: anhydrous, meets USP testing specifications (Not intended for use in preparing injectable dosage forms.)
Packaging: 500G
Price: ₹11636.88
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: PHR2669
Product name : Calcium Gluconate Anhydrous
Purity: Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 500?mg
Packaging: 500MG
Price: ₹17038.55
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: C8231
Product name : Calcium D-gluconate
Purity: anhydrous, meets USP testing specifications (Not intended for use in preparing injectable dosage forms.)
Packaging: 1KG
Price: ₹17514.85
Updated: 2022/06/14
Buy: Buy

Brand: ALFA India
Product number: ALF-044542-TJ
Product name : Calcium D-gluconate gel, 2.5% w/w aq. soln.
Purity:
Packaging: 60g
Price: ₹9702
Updated: 2022/05/26
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Calcium gluconate Chemical Properties,Usage,Production

Description Calcium gluconate is the calcium salt of gluconate, being an oxidative product of glucose containing 9.3% calcium. Calcium gluconate is a kind of mineral supplement and medication. It can be used for vein injection to treat the low blood calcium, high blood potassium, and magnesium toxicity. It is required only when there is not enough calcium in the diet. It is also used for the treatment of black widow spider bites to relieve muscle cramping and treatment of osteoporosis or rickets. It can also be used to decrease the capillary permeability in allergic conditions, nonthrombocytopenic purpura and exudative dermatoses.
References http://www.drugbank.ca/drugs/DB11126 https://en.wikipedia.org/wiki/Calcium_gluconate
Chemical Properties white crystalline powder or granules
Uses Calcium Gluconate is used as an inert ingredient in pesticide formulations applied to crops. It is also used as a supplement to fortify beverages and foods lacking a sufficient amount of calcium.
Uses In sewage purification; in coffee powders to prevent caking.
Uses analgesic, antipyretic
Uses Calcium Gluconate is a white crystalline granule or powder that functions as a firming agent, formulation aid, sequestrant, and sta- bilizer. at room temperature the anhydrous form has a solubility of approximately 1 g in 30 ml of water, which improves in boiling water to approximately 1 g in 5 ml of water. it also exists as calcium gluconate (monohydrate). it is used as a source of calcium ions for sodium alginate gels, and as a calcium fortifier in baked goods, pud- dings, and dairy product analogs. it functions as a coagulation aid in milk and instant pudding powders and as a means of masking the bitter aftertaste of some artificial sweeteners.
Definition ChEBI: Calcium gluconate is the calcium salt of D-gluconic acid. It has a role as a nutraceutical. It contains a D-gluconate.
brand name Calglucon (Novartis).
Flammability and Explosibility Non flammable
Industrial uses calcium gluconate [Ca(C₆H₁₁O₇)₂] is used as a food additive in vitamin pills.injection of a 10% calcium gluconate has been recommended. It has to be kept in mind that the plasma Ca²⁺ level and any changes to the electrocardiogram (ECG) have to be carefully monitored.
Clinical Use Hypocalcaemia
Safety Profile Moderately toxic by subcutaneous, intraperitoneal, and intravenous routes. Human systemic effects in infants by intramuscular route: dermatitis and fever. When heated to decomposition it emits acrid smoke and fumes. See also CALCIUM COMPOUNDS.
Veterinary Drugs and Treatments Calcium salts are used for the prevention or treatment of hypocalcemic conditions.
Drug interactions Potentially hazardous interactions with other drugs
Can impair absorption of some drugs, e.g. iron, ciprofloxacin.
Metabolism Calcium is absorbed mainly from the small intestine by active transport and passive diffusion. About one-third of ingested calcium is absorbed although this can vary depending upon dietary factors and the state of the small intestine. 1,25-Dihydroxycholecalciferol (calcitriol), a metabolite of vitamin D, enhances the active phase of absorption. Excess calcium is mainly excreted renally. Unabsorbed calcium is eliminated in the faeces, together with that secreted in the bile and pancreatic juice. Minor amounts are lost in the sweat, skin, hair, and nails.
Purification Methods Dissolve it in H2O, filter and precipitate it by adding MeOH. Filter off the solid and dry it in a vacuum at 85o. Alternatively, dissolve it in H2O, filter (from insoluble inorganic Ca) and evaporate it to dryness under vacuum at 85o. [March et al. J Am Pharm Assoc 41 366 1952, Beilstein 3 IV 1255.]