Description
ChemicalBook > CAS DataBase List > Benzathine benzylpenicillin

Benzathine benzylpenicillin

Description
Benzathine benzylpenicillin Structure
Benzathine benzylpenicillin
  • CAS No.1538-09-6
  • Chemical Name:Benzathine benzylpenicillin
  • CBNumber:CB0400046
  • Molecular Formula:C48H56N6O8S2
  • Formula Weight:909.12
  • MOL File:1538-09-6.mol
Benzathine benzylpenicillin Property
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22-42/43
  • Safety Statements  :36
  • WGK Germany  :3
  • RTECS  :XH9425000
  • Toxicity :LD50 orl-mus: 2000 mg/kg NIIRDN 6,774,82
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H302-H334
  • Precautionary statements P261-P264-P270-P284-P301+P312-P304+P340+P312
Benzathine benzylpenicillin Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: 31735
  • Product name : Benzathine penicilline G tetrahydrate
  • Purity: VETRANAL?, analytical standard
  • Packaging: 250MG
  • Price: ₹5033.63
  • Updated: 2022/06/14
  • Buy: Buy

Benzathine benzylpenicillin Chemical Properties,Usage,Production

  • Description Benzathine penicillin and procaine penicillin is an antibiotic that fights bacteria in your body. Benzathine penicillin and procaine penicillin is used to treat many different types of severe infections, including strep and staph infections, diphtheria, meningitis, gonorrhea, and syphilis. It is also used to prevent rheumatic fever. It is given by injection into a muscle. Belonging to a penicillin-class drug, its mechanism of action is inhibiting the cell wall synthesis of bacteria, further killing bacteria.
  • Chemical Properties White or almost white powder.
  • Originator Bicillin,Wyeth,US,1951
  • Uses The benzathine salt of penicillin G, an antibiotic used in the treatment of various bacterial infections, including Staphylococcus aureus.
  • Uses Benzathine benzylpenicillin is used as a Penicillin antibacterial.
  • Manufacturing Process Ethylenediamine (15 g, 0.25 mol) was added dropwise to 100 ml 98-100% formic acid in a two-necked 500 ml flask, fitted with an addition tube and reflux condenser with drying tube, cooled in an ice-bath. After complete addition of the base, 53 g of benzaldehyde (0.5 mol) was added in one lot. The ice-bath was removed and the flask was heated to the refluxing temperature. The initial rate of carbon dioxide evolution was too rapid to measure. After twenty minutes, the rate was circa 100 ml per minute and decreased rapidly to 8 ml per minute in one hour. Heating at reflux was continued for 35 hours.
    Following the refluxing most of the excess formic acid was removed under reduced pressure. Hydrochloric acid (200 ml 6 N) was added to the viscous amber residue and heated under reflux, After 15 minutes, bumping necessitated cooling and filtering to remove crystalline dihydrochloride, which after washing with isopropanol was dried, MP circa 300°C. The mother liquors were refluxed one hour and cooled, obtaining an additional amount of product, MP circa 300°C. The filtrate was concentrated in vacuo to 100 ml, cooled and made alkaline with 40% NaOH. The supernatant oil was extracted with ether, dried, and fractionated from a stillpot packed with glass wool and heated in a sand-bath at 320°C. The first fraction at 106°C at 0.6-0.7 mm was Nbenzylethylenediamine (dipicrate, MP 222°C). The N,N'dibenzylethylenediamine was collected at 177°C to 206°C at 0.6-1.0 mm as a colorless liquid.
    To a solution of 60 g of sodium penicillin G in 800 cc of distilled water cooled to 0°C to 4°C in an ice-bath, a solution of 35 g of N,N'dibenzylethylenediamine diacetate in 200 cc of distilled water is added dropwise with stirring. The thick slurry is filtered with suction, washed twice with 100 cc of cold water, dried by suction and spread out in a thin layer for completion of drying. The product weighed 80 g.
    The air-dried powder has a broad melting point, sintering at 100°C, melting above 110°C to a cloudy liquid becoming clear at 135°C.
  • Therapeutic Function Antibacterial
  • Clinical Use Since penicillin G benzathine, N,N'-dibenzylethylenediaminedipenicillin G (Bicillin, Permapen), is the salt of a diamine,2 moles of penicillin are available from each molecule. It isvery insoluble in water, requiring about 3,000 mL to dissolve1 g. This property gives the compound great stabilityand prolonged duration of effect. At the pH of gastric juice,it is quite stable, and food intake does not interfere with itsabsorption. It is available in tablet form and in several parenteralpreparations. The activity of penicillin G benzathineis equivalent to 1,211 units/mg.Several other amines have been used to make penicillinsalts, and research is continuing on this subject. Otheramines that have been used include 2-chloroprocaine; L-Nmethyl-1,2-diphenyl-2-hydroxyethylamine (L-ephenamine);dibenzylamine; tripelennamine (Pyribenzamine); and N,N'-bis-(dehydroabietyl)ethylenediamine (hydrabamine).
  • Safety Profile Moderately toxic by ingestion andintraperitoneal routes. Experimental reproductive effects.When heated to decomposition it emits very toxic fumesof NOx and SOx. See other penicillin entries.
Benzathine benzylpenicillin Preparation Products And Raw materials
Raw materials
Preparation Products
Benzathine benzylpenicillin Suppliers
Global(180)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29859
  • Advantage：58
  • Supplier：
    Xiamen AmoyChem Co., Ltd
  • Tel：+86-86-5926051114<br/>+8615060885618
  • Email：sales@amoychem.com
  • Country：China
  • ProdList：6383
  • Advantage：58
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
Benzathine benzylpenicillin Spectrum
1538-09-6, Benzathine benzylpenicillinRelated Search:
  • 1538-09-6
  • Organics
  • 抑制剂
  • 生化试剂
  • 化学试剂
  • 化工品
  • 化工试剂
  • 原料药
  • 医用原料
  • 原料药
  • 医用原料
  • 医药原料药-科研原料
  • 医药原料
  • 青霉素类
  • 生命科学标准品
  • 分析标准品
  • BioChemical
  • Antibiotics
  • Antibiotics A to Z
  • Antibiotics N-S
  • C16H20N22C16H18N2O4S
  • C16H20N2C16H18N2O4S2
  • C48H56N6O8S24H2O
  • C32H36N4O8S2C16H20N2
  • C48H56N6O8S2
  • 青霉素G苄星盐
  • 苄星青霉素G标准品
  • 苄星青霉素G/A1A
  • N1,N2-二苄基乙烷-1,2-二胺 双((2S,5R,6R)-3,3-二甲基-7-氧代-6-(2-苯基乙酰氨基)-4-硫代-1-氮杂双环[3.2.0]庚烷-2-甲酸盐) (1:2)
  • 苄星青霉素(苄星青霉素 G对照品)
  • 4'-甲基磺酰基-2-苯基乙基氯甲基酮
  • 苄星青霉素/苄星青霉素G
  • 苄星青霉素/苄星青霉素G+1%卵磷脂
  • 苄星青霉素 EP标准品
  • 苄星青霉素 标准品
  • 星青霉素
  • 长效西林
  • 苄星青霉素 G
  • 长效青霉素
  • 苄星青霉素
  • (2S,5R,6R)-3,3-二甲基-6-(2-苯乙酰氨基)-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸二苄基乙二胺
  • 苄星青霉素G
  • 比西林
  • 苄星青霉素G四水合物/(2S,5R,6R)-3,3-二甲基-6-(2-苯乙酰氨基)-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸二苄基乙二胺
  • 苄星青霉素杂质
  • 苄青霉素
  • 苄星青霉素(卵磷脂)
  • 青霉素 G 苄星青霉素盐 水合物
  • 苄青霉素 苄星青霉素盐 水合物
  • 1538-09-6
  • N1,N2-Dibenzylethane-1,2-diamine bis((2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate) (1:2)
  • Benzathine Pencillin G
  • permapen
  • bicillin
  • Penicillin G Benzathin
  • BENZATHINE PENICILLIN
  • Benzathine penicillin GQ: What is Benzathine penicillin G Q: What is the CAS Number of Benzathine penicillin G Q: What is the storage condition of Benzathine penicillin G Q: What are the applications of Benzathine penicillin G
  • Penicillin G Benzathine Salt with 0.2% Polysorbate 80

Home

My