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(1R)-(-)-10-Camphorsulfonic acid

L-Camphorsulfonic acid Uses Production method

CAS No.35963-20-3
Chemical Name:(1R)-(-)-10-Camphorsulfonic acid
CBNumber:CB0365888
Molecular Formula:C10H16O4S
Formula Weight:232.3
MOL File:35963-20-3.mol

(1R)-(-)-10-Camphorsulfonic acid Property

Melting point 198 °C (dec.)(lit.)
Boiling point 344.46°C (rough estimate)
alpha -22 º (c=20,H2O)
Density 1.2981 (rough estimate)
refractive index -21.5 ° (C=5, H2O)
storage temp. Store below +30°C.
solubility DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
pka 1.17±0.50(Predicted)
form Crystalline Powder
color White to slightly beige
PH 1.2-1.4 (20g/l, H2O)
optical activity [α]20/D 21°, c = 2 in H2O
Water Solubility soluble
Sensitive Hygroscopic
BRN 2809676
Stability Stable. Hygroscopic. Incompatible with strong bases, strong oxidizing agents.
InChIKey MIOPJNTWMNEORI-XVKPBYJWSA-N
CAS DataBase Reference 35963-20-3(CAS DataBase Reference)
FDA UNII Y6075I4FXE
UNSPSC Code 12352115
NACRES NA.22

Safety

Hazard Codes :C
Risk Statements :34
Safety Statements :26-36/37/39-45-24/25-27
RIDADR :UN 3261 8/PG 2
WGK Germany :3
F :3-10
TSCA :Yes
HazardClass :8
PackingGroup :III
HS Code :29147090

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H314
Precautionary statements P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363

(1R)-(-)-10-Camphorsulfonic acid Price More Price(13)

Brand: Sigma-Aldrich(India)
Product number: 8.40094
Product name : (1R)-(-)-Camphor-10-sulfonic acid
Purity: for synthesis
Packaging: 10G
Price: ₹3039.99
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 8.40094
Product name : (1R)-(-)-Camphor-10-sulfonic acid
Purity: for synthesis
Packaging: 100G
Price: ₹20850
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 282146
Product name : (1R)-(−)-10-Camphorsulfonic acid
Purity: 98%
Packaging: 25G
Price: ₹2468.1
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 282146
Product name : (1R)-(−)-10-Camphorsulfonic acid
Purity: 98%
Packaging: 100G
Price: ₹7674.93
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 21365
Product name : (−)-Camphor-10-sulfonic acid
Purity: purum, ≥98.0% (T)
Packaging: 50G
Price: ₹6310.98
Updated: 2022/06/14
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(1R)-(-)-10-Camphorsulfonic acid Chemical Properties,Usage,Production

L-Camphorsulfonic acid Camphor sulfonic acid includes L-camphor sulfonic acid, D-camphor sulfonic acid and racemic camphor sulfonic acid these three isomers.
It is a kind of white columnar crystals with the melting point of 193°C (decomposition). [α]D20+24° (water). It is Slightly soluble in ethanol, insoluble in ether, soluble in sodium hydroxide and sodium carbonate solution. L-camphor sulfonic acid could be produced from reaction between camphor, sulfuric acid and acetic anhydride.It has a lot of functions such as exciting the respiratory center, the vascular movement center and myocardium. Its sodium salt plays pharmaceutical role in medicine.
Camphor sulfonic acid sodium salt is a kind of white crystalline powder. It is odorless and tastes bitter and then sweet. It is easily absorb moisture and easily dissolve in the water and hot ethanol. So it should be shading confined preservation. it can Directly excite the medulla oblongata respiratory center and vascular movement center, and quicken and deepen the breath, rise the blood pressure; it also can directly excite the myocardium and strength the contraction of cardiac muscle as well as could increase the output.
It is applied the treatment of infectious disease, as well as the disease like central inhibition of poisoning caused by respiratory depression, fatigue, high fever, poisoning, heat stroke and other acute heart failure.
Uses (1) It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent.
Production method Camphor sulfonic acid is obtained from camphor and sulfuric acid by irradiation.
This method involves:
1) Adding the camphor and acetic anhydride to the pot.
2) Mixing it and making it dissolved.
3) Dripping sulfuric acid after cooling. And the reaction should be maintained at 44-45 °C for 48 hours. Then cool it to 6-7 °C.
4) Crystallizing, filtrating, washing with a small amount of acetic acid crystals, and dry it to get camphor sulfonic acid.
Physical properties (1R)-(-)-10-Camphorsulfonic acid is a kind of prismatic crystals and its melting point is 193-195 ° C (decompose). It is Insoluble in ether and slightly soluble in glacial acetic acid and ethyl acetate. And it is and moisture in wet air.
Uses (1R)-(-)-Camphor-10-sulfonic acid, is used as a pharamaceutical intermediate and also used as a chiral derivative of Camp. It can also be used as resolving agents for chiral amines and other cations.
Uses 1R)-(-)-10-Camphorsulfonic acid is a chiral derivative of Camphor.It has the following uses:
(1)It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent.
Definition ChEBI: The R enantiomer of camphorsulfonic acid.
General Description (1R)-(-)-10-Camphorsulfonic acid is an HPLC derivatization reagent for UV/Vis detection. It is mainly employed for the resolution of bases.
Purification Methods It forms prisms from AcOH or EtOAc, and is deliquescent in moist air. Store it in tightly stoppered bottles. The NH4 salt forms needles from H2O [] D ±20.5o (c 5, H2O). [Burgess & Lowry J Chem Soc 127 279 1925, Marsi et al. J Am Chem Soc [ 78 3063 1956.] The RS-acid recrystallises from AcOH. [60g of (±)-acid in 60mL of AcOH at 105o gave 40g of crystals has m 202-203o [Bartlett & Knox Org Synth 45 12 1965.] [Beilstein 11 IV 642.]