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Rucaparib Camsylate

Rucaparib Camsylate Structure
Rucaparib Camsylate
  • CAS No.1859053-21-6
  • Chemical Name:Rucaparib Camsylate
  • CBNumber:CB03147535
  • Molecular Formula:C29H34FN3O5S
  • Formula Weight:555.67
  • MOL File:1859053-21-6.mol
Rucaparib Camsylate Property
  • storage temp. Store at -20°C
  • solubility DMSO:79.63(Max Conc. mg/mL);143.31(Max Conc. mM)
  • form Solid
  • color Light yellow to gray
  • NCI Dictionary of Cancer Terms rucaparib camsylate
  • FDA UNII 41AX9SJ8KO
  • NCI Drug Dictionary rucaparib camsylate
  • UNSPSC Code 12352202
  • NACRES NA.77
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H361-H341
  • Precautionary statements P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501

Rucaparib Camsylate Chemical Properties,Usage,Production

  • Uses Rucaparib Camsylate is a novel DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1) inhibitor.
  • Definition ChEBI: Rucaparib camsylate is a camphorsulfonate salt obtained by reaction of rucaparib with one molar equivalent of (1S,4R)-camphorsulfonic acid. It is an inhibitor of poly (ADP-ribose) polymerase and is used as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor. It is a camphorsulfonate salt and an azepinoindole. It contains a (S)-camphorsulfonate and a rucaparib(1+).
  • Biological Activity Rucaparib is an inhibitor of the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It has been found to have anticancer activity in a number of cancers and has been approved for treatment of previously treated, BRCA-mutant ovarian cancer.
  • in vivo

    Rucaparib (AG014699) monocamsylate and AG14584 significantly increase Temozolomide toxicity. Rucaparib (1 mg/kg) monocamsylate significantly increases Temozolomide-induced body weight loss. Rucaparib (0.1 mg/kg) monocamsylate results in a 50% increase in the temozolomide-induced tumor growth delay[1].
    Rucaparib (10 mg/kg for i.p. or 50, 150 mg/kg for p.o.; daily for 5 days per week for 6 weeks) monocamsylate significantly inhibits the growth of the tumor, and there is one complete tumor regression and two persistent partial regressions[2].
    Rucaparib (150 mg/kg; p.o.; once per week for 6 weeks or three times per week for 6 weeks) monocamsylate has greatest antitumor effect with three complete regressions[2].
    Rucaparib monocamsylate enhances the antitumor activity of temozolomide and indicates complete and sustained tumor regression in NB1691 and SHSY5Y xenografts[6].

    Animal Model:Female CD-1 nude mice aged 10-12 weeks with Capan-1 cells[2]
    Dosage:10?mg/kg or 50, 150 mg/kg
    Administration:10?mg/kg for i.p. or 50, 150 mg/kg for p.o.
    Result:Significantly inhibited the growth of the tumor.
  • IC 50 PARP-1: 1.4 nM (Ki); PARP-2; PARP-3
  • storage Store at -20°C
Rucaparib Camsylate Preparation Products And Raw materials
Raw materials
Preparation Products
Rucaparib Camsylate Suppliers
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Rucaparib Camsylate Spectrum
1859053-21-6, Rucaparib CamsylateRelated Search:
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  • 瑞卡帕布樟脑磺酸盐|||RUCAPARIB CAMSYLATE
  • 瑞卡帕布樟脑磺酸
  • PARP抑制剂(RUCAPARIB CAMSYLATE)
  • 英文同义词: RUCAPARIB CAMSYLATE
  • 芦卡帕利
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  • 1859053-21-6
  • Rucaparib monocamsylate, 10 mM in DMSO
  • Asciminib Impurity 1
  • 8-Fluoro-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate
  • Rucaparib monocamsylate
  • 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H- azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7dimethyl-2-oxobicyclo [2.2.1] hept-1-yl) methanesulfonic acid salt
  • Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-, compd. with 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one (1:1)
  • Rucaparib Camphosulfonate
  • 8‐Fluoro‐2‐(4‐methylaminomethyl‐phenyl)‐1,3,4,5‐tetrahydro‐azepino[5,4,3‐cd] indol‐6‐one (S)‐camphorsulfonate Salt
  • Rucaparib Camsylate

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