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3-ACETYL-BETA-BOSWELLIC ACID

3-ACETYL-BETA-BOSWELLIC ACID Structure
3-ACETYL-BETA-BOSWELLIC ACID
  • CAS No.5968-70-7
  • Chemical Name:3-ACETYL-BETA-BOSWELLIC ACID
  • CBNumber:CB0133948
  • Molecular Formula:C32H50O4
  • Formula Weight:498.74
  • MOL File:5968-70-7.mol
3-ACETYL-BETA-BOSWELLIC ACID Property
  • Melting point 157-161℃
  • Boiling point 567℃
  • Density 1.09
  • Flash point 171℃
  • storage temp. -20°C Freezer
  • solubility Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Very Sligh
  • pka 4.32±0.70(Predicted)
  • form Solid
  • color White to Off-White
  • LogP 10.270 (est)
  • FDA UNII 5M3483EOU5
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

3-ACETYL-BETA-BOSWELLIC ACID Chemical Properties,Usage,Production

  • Uses Boswellic acids are pentacyclic triterpenes first isolated from the resin of Boswellia plants. They have anti-inflammatory and anti-arthritic actions in mice. β-acetyl-Boswellic acid is a non-reducing inhibitor of 5-lipoxygenase (5-LO) that shows selectivity for 5-LO over 12-LO or COX. When studied as a 1:1 mixture with α-acetyl-boswellic acid, it inhibits topoisomerase II activity and arrests cell cycling or induces apoptosis in cancer cells.[Cayman Chemical]
  • Biological Activity β-acetyl-boswellic acid is a specific, nonreducing-type inhibitor of the 5-lo product formation with selectivity over 12-lo and cox [1][2].5-lipoxygenase (5-lo) is a member of the lipoxygenase family of enzymes and transforms efa substrates into leukotrienes.in rat peritoneal neutrophils, boswellic acids concentration dependently decreased the formation of leukotriene b4 from endogenous arachidonic acid. in isolated human platelets, boswellic acids in concentrations up to 400 μm did not impair the cyclooxygenase and 12-lipoxygenase [1]. in calcium/calcium ionophore-stimulated peritoneal neutrophils of rats, boswellic acids significantly decreased production of ltb4 and total 5-lipoxygenase products with ec50 value of about 30 μg/ml [2]. in six human myeloid leukemia cell lines, boswellic acid acetate, a 1:1 mixture of α-boswellic acid acetate and β-boswellic acid acetate induces apoptosis through caspase-mediated pathways [4].boswellic acids are pentacyclic triterpenes with putative anti-inflammatory effects. in a mouse model of osteoarthritis (oa), boswellic acid significantly attenuated articular cartilage erosion and significantly reduced knee synovitis and osteophyte formation. in synovium of mice, boswellic acid directly inhibit il-1β and tlr4 induced inflammatory cytokines production [3].
  • References [1]. safayhi h, mack t, sabieraj j, et al. boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. j pharmacol exp ther. 1992 jun;261(3):1143-6.
    [2]. ammon hp, safayhi h, mack t, et al. mechanism of antiinflammatory actions of curcumine and boswellic acids. j ethnopharmacol. 1993 mar;38(2-3):113-9.
    [3]. wang q, pan x, wong hh, et al. oral and topical boswellic acid attenuates mouse osteoarthritis. osteoarthritis cartilage. 2014 jan;22(1):128-32.
    [4]. xia l, chen d, han r, et al. boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells. mol cancer ther. 2005 mar;4(3):381-8.
3-ACETYL-BETA-BOSWELLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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3-ACETYL-BETA-BOSWELLIC ACID Spectrum
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  • 3-<i>O</i>-Acetyl-β-boswellic acid
  • (3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-3-Acetoxy-4,6a,6b,8a,11,12,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid
  • 3-ACETYL-BETA-BOSWELLIC ACID USP/EP/BP
  • β-acetyl-Boswellic Acid
  • 3-Acetyl-β-boswellic acid
  • Urs-12-en-23-oic acid, 3-(acetyloxy)-, (3α,4β)-
  • 3α-Hydroxyurs-12-en-24-oic acid acetate
  • (3α,4β)-3-(Acetyloxy)urs-12-en-23-oic acid
  • 3-O-Acetyl-beta-boswellic acid
  • 3(3alpha,4beta)-(acetyloxy)urs-12-en-23-oic acid
  • 3α-Acetoxyoleana-12-ene-24-oic acid
  • (4R)-3α-Acetoxyolean-12-en-24-oic acid
  • (18β)-3α-Acetoxygermanica-12-ene-24-oic acid
  • O-Acetyl-β-boswellic acid
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  • B-ACETYLBOSWELLIC ACID
  • 3-O-ACETYL-BOSWELLIC ACID, BOSWELLIA SP, >98%
  • 3-O-Acetyl--boswellicacid,Boswelliasp
  • 3-Acetyl-(-boswellicacid
  • BOSWELLIC ACID, 3-ACETYL
  • BETA-ACETYLBOSWELLIC ACID
  • 3-ACETYL-BETA-BOSWELLIC ACID
  • ACETYL-B-BOSWELLIC ACID, 3-

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