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11-KETO-BETA-BOSWELLIC ACID

CAS No.17019-92-0
Chemical Name:11-KETO-BETA-BOSWELLIC ACID
CBNumber:CB1415526
Molecular Formula:C30H46O4
Formula Weight:470.68
MOL File:17019-92-0.mol

11-KETO-BETA-BOSWELLIC ACID Property

Melting point 190～192℃
Boiling point 591.8±50.0 °C(Predicted)
Density 1.14±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility ≤5mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
pka 4.46±0.70(Predicted)
form Solid
color White
Water Solubility insoluble in water
InChIKey YIMHGPSYDOGBPI-IQQSWPBXSA-N
LogP 7.100 (est)
FDA UNII 0S3BIF6H0Q
UNSPSC Code 85151701
NACRES NA.24

Safety

WGK Germany :3
HS Code :29189900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

11-KETO-BETA-BOSWELLIC ACID Price More Price(1)

Brand: Sigma-Aldrich(India)
Product number: 78535
Product name : 11-Keto-β-boswellic acid
Purity: analytical standard
Packaging: 5MG
Price: ₹40593.75
Updated: 2022/06/14
Buy: Buy

11-KETO-BETA-BOSWELLIC ACID Chemical Properties,Usage,Production

Uses A constitutent of frankincense (olibanum) with anti-inflammatory properties. It has been shown to trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells.
Biological Activity 37.9 μm: blocks a2780 (cis-platin resistant ovarian cancer cells) [1].11-keto-β-boswellic acid, known as kba, is a naturally occurring pentacyclic triterpene isolated from the gum resin of the tree boswellia serrata. kba is non-redox, specific leukotriene synthesis inhibitors through the inhibition of 5-lipoxygenase (5-lox) which has anti-arthritic and anti-inflammatory activities. 5-lox catalyzes essential fatty acids substrates into leukotrienes and a variety of other biologically active products. kba is a novel activator of nuclear factor erythroid-2-related factor 2 (nrf2), which protects against cerebral ischemic injury.
in vitro kba, concentration dependently, decreased the formation of leukotriene b4 and the synthesis of all 5-lox products from endogenous arachidonic acid in rat peritoneal neutrophils. in contrast, kba exerted no remarkable effects on the 12-lipoxygenase and cyclooxygenase activities. [2].
in vivo adult male sprague–dawley rats were injected kab intraperitoneally at a dose of 25 mg/kg for 48 hours. kab remarkably decreased infarct volumes as well as apoptotic cells at 1 h, and then increased neurologic scores when applied 48 h. moreover, posttreatment with kba induced the decrease of malondialdehyde levels and the increase of protein nrf2 and heme oxygenase-1 expression in brain tissues, indicating that the nrf2/ho-1 pathway was involved in the neuroprotection of kba against oxidative stress-induced ischemic injury [3].
IC 50 35.8 μm: inhibits mcf-7 (human breast adenocarcinoma) [1].
References [1]. csuk, r., barthel-niesen, a., barthel, a., schffer, r., & al-harrasi, a. 11-keto-boswellic acid derived amides and monodesmosidic saponins induce apoptosis in breast and cervical cancers cells. european journal of medicinal chemistry. 2015; 100: 98-105.
[2]. safayhi, h., mack, t. h. o. m. a. s., sabieraj, j. o. a. c. h. i. m., anazodo, m. i., subramanian, l. r., & ammon, h. p. boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. journal of pharmacology and experimental therapeutics. 1992; 261(3):1143-1146.
[3]. ding, y., chen, m., wang, m., li, y., & wen, a. posttreatment with 11-keto-β-boswellic acid ameliorates cerebral ischemia–reperfusion injury: nrf2/ho-1 pathway as a potential mechanism. molecular neurobiology. 2014; 52(3): 1430-1439.