α-Amyrin (50, 100, 200 mg/kg orally, once daily for 42 days) can reduce the survival rate of rats with metabolic syndrome induced by high fructose diet[2].
α-Amyrin (2 or 4 mg/kg, orally) improves cognitive dysfunction caused by low cholinergic neurotransmission in mice by activating ERK and GSK-3β signaling pathways[3].
| Animal Model: | High-fructose diet (HFD)-induced metabolic syndrome in rats[2] |
| Dosage: | 50, 100, 200 mg/kg |
| Administration: | p.o. |
| Result: | Decreased systolic blood pressure, plasma glucose, total cholesterol, and plasma triglycerides.
Attenuated hepatic oxidative stress as well as micro- and macrovesicular fatty changes in hepatocytes caused by HFD.
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| Animal Model: | Scopolamine-Induced Memory Impairment Mice[3] |
| Dosage: | 2 or 4 mg/kg |
| Administration: | p.o. |
| Result: | Increased the expression levels of phosphorylated extracellular signal-regulated kinase 1/2 (pERK) and phosphorylated glycogen synthase kinase-3β (pGSK-3β). |
