Description
Lignoceric acid is a 24-
carbon saturated (24:0) fatty acid. In mammals, it is synthesized during brain development and is found in cerebrosides. The deficient peroxisomal oxidation of very-
long-
chain fatty acids, including lignoceric acid, contributes to certain syndromes, including Zellweger cerebro-
hepato-
renal syndrome and X chromosome-
linked adrenoleukodystrophy. Lignoceric acid is also a by-
product of lignin production.
Chemical Properties
white shiny crystalline powder or flakes
Uses
Tetracosanoic Acid is a chemical component of a dried mushroom powder exhibiting antioxidant properties. It is a long chain fatty acid present in peanut oil.
Definition
ChEBI: A C24 straight-chain saturated fatty acid.
Purification Methods
Crystallise the acid from acetic acid, Me2CO, toluene, pet ether/Me2CO or*C6H6/Me2CO. [Beilstein 2 IV 1301.]
References
[1] J M BOURRE. Lignoceric acid biosynthesis in the developing brain. Activities of mitochondrial acetyl-CoA-dependent synthesis and microsomal malonyl-CoA chain-elongating system in relation to myelination. Comparison between normal mouse and dysmyelinating mutants (quaking and jimpy).[J]. European journal of biochemistry, 1977, 72 1: 41-47. DOI:
10.1111/j.1432-1033.1977.tb11222.x[2] I SINGH. Lignoceric acid is oxidized in the peroxisome: implications for the Zellweger cerebro-hepato-renal syndrome and adrenoleukodystrophy.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1984, 81 13: 4203-4207. DOI:
10.1073/pnas.81.13.4203
