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Succimer

Succimer Structure
Succimer
  • CAS No.304-55-2
  • Chemical Name:Succimer
  • CBNumber:CB9142563
  • Molecular Formula:C4H6O4S2
  • Formula Weight:182.22
  • MOL File:304-55-2.mol
Succimer Property
  • Melting point: :196-198 °C (dec.)(lit.)
  • Boiling point: :285.62°C (rough estimate)
  • Density  :1.439 (estimate)
  • refractive index  :1.5220 (estimate)
  • storage temp.  :-20°C
  • pka :pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C)
  • form  :Powder
  • color  :White to off-white
  • Water Solubility  :Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear).
  • Merck  :14,8865
  • BRN  :1725150
  • Stability: :Stable. Combustible. Incompatible with strong oxidizing agents.
  • InChIKey :ACTRVOBWPAIOHC-XIXRPRMCSA-N
  • CAS DataBase Reference :304-55-2(CAS DataBase Reference)
  • FDA UNII :DX1U2629QE
  • NCI Drug Dictionary :Chemet
  • EPA Substance Registry System :Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel- (304-55-2)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements H315-H319-H335-H361
  • Precautionary statements P201-P261-P280-P305+P351+P338-P405-P501a
Succimer Price More Price(11)
  • Brand: Sigma-Aldrich
  • Product number: D7881
  • Product name : meso-2,3-Dimercaptosuccinic acid
  • Purity: ~98%
  • Packaging: 1g
  • Price: $29.4
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: D7881
  • Product name : meso-2,3-Dimercaptosuccinic acid
  • Purity: ~98%
  • Packaging: 5g
  • Price: $83.8
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: D1722
  • Product name : meso-2,3-Dimercaptosuccinic Acid
  • Purity: >98.0%(T)
  • Packaging: 5g
  • Price: $65
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: D1722
  • Product name : meso-2,3-Dimercaptosuccinic Acid
  • Purity: >98.0%(T)
  • Packaging: 25g
  • Price: $253
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: A17909
  • Product name : meso-2,3-Dimercaptosuccinic acid, 97%
  • Purity: 
  • Packaging: 5g
  • Price: $81.4
  • Updated: 2021/03/22
  • Buy: Buy

Succimer Chemical Properties,Usage,Production

  • Description Succimer is a newly available oral chelator of lead and other heavy metals. The compound is indicated for the treatment of lead poisoning in children. Succimer does not bind iron, calcium or magnesium and preferentially binds lead, mercury and arsenic over copper or zinc. The metal-bound succimer is excreted in the urine. The drug may also be effective in adults.
  • Chemical Properties white or off-white powder
  • Originator Johnson and Johnson (J&J) (U.S.A.)
  • Uses A selective masking agent for cadmium in EDTA titration of zinc.
  • Uses chelating agent, antihypertensive
  • Uses meso-2,3-Dimercaptosuccinic Acid is used as a chelating agent and masking agent for cadmium in EDTA titration of zinc.
  • Uses chelating agent, treatment of lead poisoning
  • Uses A water-soluble chelating agent.
  • Uses Chelating agent.
  • Definition ChEBI: A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.
  • brand name Chemet (Ovation).
  • Pharmaceutical Applications Dimercaptosuccinic acid (DMSA) is a modification of BAL containing two thiol groups, which are responsible for the unpleasant smell, and two carboxylic acid groups. DMSA is also known under the name Succimer. It chemical name is meso-2,3-dimercaptosuccinic acid and the chemical formula is HO2CCH(SH)CH(SH)CO2H. There are two diastereomeric forms, meso and the chiral DL forms, with the meso isomer being used as chelating agent.
    DMSA was developed in the 1960s and replaced BAL and edetate in some countries for the treatment of lead, arsenic and mercury poisoning. Furthermore, the dimethylester modification of DMSA has been successfully used for the treatment of heavy-metal poisoning.
  • Pharmaceutical Applications The unlicensed drug Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) may be valuable in the treatment of most forms of heavy-metal poisoning including lead, arsenic and mercury. These and other chelating agents such as unithiol (DMPS, 2,3-dimercapto-1-propanesulfonic acid) and α-lipoic acid (ALA) are also used in alternative medicine, which has led to much criticism and discussion. So far, no medical study has proven the effectiveness of chelation therapy for any clinical application other than heavy-metal poisoning.
  • Veterinary Drugs and Treatments In veterinary medicine, succimer may be useful for the oral treatment of lead poisoning in small animals (including birds). Potentially, it also may be of benefit for the treatment of other toxic heavy metals such as arsenic or mercury, but more research must be done before this can be recommended.
  • Purification Methods Purify the acid by dissolving it in NaOH and precipitating with dilute HCl, drying and recrystallising from MeOH. IR has at 2544 (SH) and max 1689 (CO2H) cm-1 . The bis-S-acetyl derivative has m 183-185o (from EtOAc or Me2CO), and its Me ester has m 119-120o (from pet ether) [Gerecke et al. Helv Chim Acta 44 957 1961, Owen & Sultanbawa J Chem Soc 3112 1949]. [Beilstein 3 III 1033.]
Succimer Preparation Products And Raw materials
Raw materials
Preparation Products
Global(338)Suppliers
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304-55-2, SuccimerRelated Search:
  • (2R,3S)-2,3-diMercaptosuccinic acid
  • (2R,3S)-rel-2,3-DiMercaptosuccinic acid
  • Butanedioic acid,2,3-diMercapto-, (2R,3S)-rel-
  • <i>meso</i>-2,3-Dimercaptosuccinic acid
  • API Succimer
  • -rel-2,3-Dimercaptosuccinic acid
  • (2S,3R)-2,3-dimercaptobutanedioate
  • (r*,s*)-2,3-dimercaptobutanedioicacid
  • 2,3-dimercapto-,(r*,s*)-butanedioicaci
  • 2,3-dimercapto-,(theta,s)-butanedioicaci
  • 3-dimercapto-meso-succinicaci
  • 2,3-DITHIO-MESO-TARTARIC ACID
  • 2,3-BIS-SULFANYLBUTANEDIOIC ACID
  • 2,3-DIMERCAPTOSUCCINICACIDMESO
  • MESO-DMSA
  • 2,3-DITHIOSUCCINICACID
  • 2,3-dimercapto-, ( theta,s)-butanedioic acid
  • 2,3-dimercapto-, (r*,s*)-butanedioic acid
  • 3-dimercapto- meso-succinic acid
  • MESO-2,3-DIMERCAPTOSUCCINIC ACIDF&D VERS ION
  • MESO-2,3-DIMERCAPTO SUCCINIC ACID ENTERPRISE STANDARD =98.5%
  • DimercaptosuccinicAcid(Dmsa)
  • 2,3-Dimercaptosuccinic
  • rel-(2R,3S)-2,3-Dimercaptobutanedioic acid
  • chemet
  • dim-sa
  • meso-2,3-dithiosuccinicacid
  • meso-dimercaptosuccinicacid
  • ro1-7977
  • SUCCIMER
  • DMSA
  • MESO-2,3-DIMERCAPTOSUCCINIC ACID
  • meso-2,3-Dimercaptosuccinic acid,98%
  • 2,3-DIMERCAPTO SUCCINIC ACID (DMSA) extrapure
  • 2,3-Dithio-meso-tartaric acid, DMSA, Succimer
  • meso-2,3-Dimercaptosuccinic acid,2,3-Dithio-meso-tartaric acid, DMSA, Succimer
  • Meso-2,3-DiMercaptosuccinic acid(DMSA,SucciMer)
  • DMSA (Meso-2,3-diMercaptosuccinic acid)
  • Meso-2,3-DiMercaptosuccinic acid, 98% 5GR
  • meso-2,3-DimercaptosuccinicAcid&gt
  • DMSA Succimer
  • Succimer USP/EP/BP
  • meso-2,3-Dimercaptosuccinic acid (DMSA)
  • 304-55-2
  • HO2CCHSHCHSHCO2H
  • C4H4O4S2
  • C4H6O4S2
  • Building Blocks
  • Radiopharmaceutical Chemistry (Chelating Reagents)
  • Ligands for Pharmaceutical Research
  • Organic Building Blocks
  • Sulfur Compounds
  • Thiols/Mercaptans
  • API
  • Inhibitors
  • Organic acids
  • Analytical Chemistry
  • Ligands for Pharmaceutical Research