Uses Application Mechanism of action Drugs for enhancing female sexuality
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Flibanserin

Uses Application Mechanism of action Drugs for enhancing female sexuality
Flibanserin Structure
Flibanserin
  • CAS No.167933-07-5
  • Chemical Name:Flibanserin
  • CBNumber:CB91178756
  • Molecular Formula:C20H21F3N4O
  • Formula Weight:390.4
  • MOL File:167933-07-5.mol
Flibanserin Property
  • Density  :1.292±0.06 g/cm3(Predicted)
  • storage temp.  :2-8°C
  • solubility  :DMSO: soluble10mg/mL, clear
  • pka :12.12±0.30(Predicted)
  • form  :powder
  • color  :white to beige
  • InChIKey :PPRRDFIXUUSXRA-UHFFFAOYSA-N
  • FDA UNII :37JK4STR6Z
Safety
  • Hazard Codes  :T
  • Risk Statements  :25-36/37/38
  • Safety Statements  :26-45
  • RIDADR  :UN 2811 6.1 / PGIII
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301-H315-H319-H335
  • Precautionary statements P261-P301+P310-P305+P351+P338
Flibanserin Price More Price(6)
  • Brand: Sigma-Aldrich
  • Product number: SML0797
  • Product name : Flibanserin
  • Purity: ≥98% (HPLC)
  • Packaging: 5mg
  • Price: $69.5
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: SML0797
  • Product name : Flibanserin
  • Purity: ≥98% (HPLC)
  • Packaging: 25mg
  • Price: $281
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 19203
  • Product name : Flibanserin
  • Purity: ≥98%
  • Packaging: 10mg
  • Price: $86
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 19203
  • Product name : Flibanserin
  • Purity: ≥98%
  • Packaging: 5mg
  • Price: $45
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 19203
  • Product name : Flibanserin
  • Purity: ≥98%
  • Packaging: 25mg
  • Price: $169
  • Updated: 2020/06/24
  • Buy: Buy

Flibanserin Chemical Properties,Usage,Production

  • Uses Filbanserin is an agonist of serotonin-5HT1A receptor and an antagonist of the 5-HT2A receptor. Binds dopamine receptors with Ki values ranging from 4-24 nM. Used to treat hypoactive sexual desire disorder in females.
  • Application Flibanserin is an N-alkylpiperazine that is 1-[2-(1,3-dihydro-2-oxobenzimidazol-1-yl)ethyl]piperazine in which the remaining amino proton is replaced by a 3-(trifluoromethyl)phenyl group. A multifunctional serotonin agonist and antagonist which is used for the treatment of pre-menopausal women with hypoactive sexual desire disorder. Flibanserin has a role as a serotonergic agonist, a serotonergic antagonist and an antidepressant. Flibanserin is a member of benzimidazoles, a N-arylpiperazine, a N-alkylpiperazine and an organofluorine compound.
  • Mechanism of action Flibanserin is a novel multifunctional serotonin agonist and antagonist (MSAA) that improves sexual functioning in premenopausal women who suffer from reduced sexual interest and desire.Flibanserin theoretically improves sexual functioning by enhancing downstream release of dopamine and norepinephrine while reducing serotonin release in the brain circuits that mediate symptoms of reduced sexual interest and desire.
    Flibanserin has demonstrated clinical efficacy in premenopausal women who have reduced interest in and desire for sex and has 2 principal pharmacologic actions in microcircuits: it is a full agonist at postsynaptic serotonin 5HT1A receptors and an antagonist at postsynaptic 5HT2A receptors..Flibansetrin has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin binds equally to 5-HT1A and 5-HT2A receptors.
  • Drugs for enhancing female sexuality Flibanserin is the world's first New drug for enhancing female sexuality. It can reduce the amount of 5-hydroxytryptamine which inhibits sexuality and improve sexual stimulant dopamine levels. It is already submitted to Food and Drug Administration of the United States for approval.
    This drug can directly effect on the  sexual pleasure control area of the female brain to restore female Flagging libido. By adjusting the aphrodisiac body system, Flibanserin Helps to restore the balance of sexual appetite suppression and exciting mechanism and lead to form a healthy sexual performance. The curative effect can be obtained a few weeks later. At the same time, the female viagra also has a certain side effects. One-eighth of tested women appeared dizziness, fatigue and sleepiness.
    Similar to antidepressants, Flibanserin will affect the brain secretion chemicals associated with emotions and desires. In fact, it was used as a drug for the treatment of depression before before it becomes a sex medicine.
    Different from the working principle of "viagra", Flibanserin works by adjusting the chemicals in female brains.
    In addition, "viagra" only works for most men, Flibanserin has effects on women with low libido. If the patient does not have a sexual interest to someone, Flibanserin will not affect her. Flibanserin will not cause hyperaphrodisia. Clayton. Anita, adviser of the drug companies says :“it is not an aphrodisiac and it only helps to balance the chemicals in the female brain to make a female restore sex desire, but not more than the normal level. However, it takes some time for this drug to work and women should take the drug every day.
    Flibanserin tablet
    Figure 1 shows Flibanserin tablet.
  • Uses Antidepressant (5-HT1a agonist and 5-HT2 antagonist).
Flibanserin Preparation Products And Raw materials
Raw materials
Preparation Products
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  • API
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