Chemical Properties
Methanol is derived from the dried leaves of Turpinia arguya Seem of the Turpinaceae family.
Uses
Rhoifolin is a flavone, a type of flavonoid, a new natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea. Rhoifolin has been shown to be an apigenin-7-rhamnoglucoside. Rhoifolin apparently is identical with the apigenin-7-rhamnoglucoside obtained by the bromination and dehydrobromination of Naringin (N378980).
Definition
ChEBI: Apigenin 7-O-neohesperidoside is an apigenin derivative having an alpha-(1->2)-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group. It has a role as a metabolite. It is a neohesperidoside, a dihydroxyflavone and a glycosyloxyflavone. It is functionally related to an apigenin.
in vivo
Rhoifolin (12, 24, 30, 36, and 40 mg/kg; PO, for 7 days) has radioprotective effect against radiation-induced decrease of blood platelets and cardiac biochemical lesions in whole body irradiated mice[4].
| Animal Model: | Swiss albino mice (10 Gy irradiation induced certain haematological and cardiac biochemical abnormalities)[4] |
| Dosage: | 12, 24, 30, 36, and 40 mg/kg |
| Administration: | PO, for 7 days |
| Result: | Diminished the toxic effect of radiation by decreasing the level of lipid peroxides measured as malondialdehyde, ameliorating the alterations in nitric oxide, lactate dehydrogenase, creatine kinase in plasma and tissue and the plasma lipid profile. |
IC 50
insulin receptor-β; GLUT4; NF-κB; MAPK
