2-Nitro-N-hydroxyethyl aniline

Chemical Properties

Uses

Flammability and Explosibility

Synthesis

141-43-5

88-73-3

4926-55-0

In a 1L three-necked flask, 100 g of o-chloronitrobenzene, 450 g of hexane and 10 g of sodium fluoride were added sequentially and the temperature was raised to 80 °C. 60g of ethanolamine was slowly added dropwise, and the reaction temperature was maintained at 80°C for 20 hours. Sampling and analysis were carried out during the reaction, monitored by HPLC, and the reaction was terminated when the content of o-chloronitrobenzene was less than 3%. Upon completion of the reaction, decompression distillation was carried out to remove the solvent and the distillation temperature was controlled at 90 °C. Subsequently, methanol and water were added for crystallization, and after filtration, washing and drying, 103 g of red crystalline powder N-(2-nitrophenyl)ethanolamine was obtained, with a purity of 99.6% by HPLC.

References