Chemical Properties
White Solid
Originator
Preludin, Boehringer Ingelheim, US ,1956
Uses
Anorexic.
Controlled substance (stimulant).
Definition
ChEBI: Phenmetrazine hydrochloride is an organic molecular entity.
Manufacturing Process
10 grams of β-phenyl-α-methyl-β,β'-dihydroxy-diethylamine hydrochloride (produced by hydrogenation in the presence of palladium and charcoal of βphenyl-α-methyl-β-keto-β'-hydroxy-N-benzyl-diethylamine hydrochloride obtained from bromopropiophenone by reacting with benzyl-ethanolamine), are warmed with 10% hydrochloric acid for 6 hours on a water bath.After working up in the usual manner, the hydrochloride of the 2-phenyl-3methyl-morpholine crystallizes out from methanolic hydrochloric acid and acetone, MP = 182°C, according to US Patent 2,835,669.
brand name
Preludin (Boehringer Ingelheim).
Therapeutic Function
Antiobesity
Safety Profile
Poison by ingestion,
intravenous, intraperitoneal, and
subcutaneous routes. Human reproductive
effects. Human teratogenic effects by
ingestion: developmental abnormalities of
the respiratory and gastrointestinal systems,
and effects on newborn including neonatal
measures or effects. When heated to
decomposition it emits very toxic fumes of
NOx and HCl.
