Preludin, Boehringer Ingelheim, US ,1956
Anorexic.
Controlled substance (stimulant).
ChEBI: Phenmetrazine hydrochloride is an organic molecular entity.
10 grams of β-phenyl-α-methyl-β,β'-dihydroxy-diethylamine hydrochloride (produced by hydrogenation in the presence of palladium and charcoal of βphenyl-α-methyl-β-keto-β'-hydroxy-N-benzyl-diethylamine hydrochloride obtained from bromopropiophenone by reacting with benzyl-ethanolamine), are warmed with 10% hydrochloric acid for 6 hours on a water bath.After working up in the usual manner, the hydrochloride of the 2-phenyl-3methyl-morpholine crystallizes out from methanolic hydrochloric acid and acetone, MP = 182°C, according to US Patent 2,835,669.
Preludin (Boehringer Ingelheim).
Poison by ingestion,
intravenous, intraperitoneal, and
subcutaneous routes. Human reproductive
effects. Human teratogenic effects by
ingestion: developmental abnormalities of
the respiratory and gastrointestinal systems,
and effects on newborn including neonatal
measures or effects. When heated to
decomposition it emits very toxic fumes of
NOx and HCl.
