Chemical Properties
White Solid
Uses
Anorexic.
Controlled substance (stimulant).
Brand name
Preludin (Boehringer Ingelheim).
Originator
Preludin, Boehringer Ingelheim, US ,1956
Definition
ChEBI: Phenmetrazine hydrochloride is an organic molecular entity.
Manufacturing Process
10 grams of β-phenyl-α-methyl-β,β'-dihydroxy-diethylamine hydrochloride (produced by hydrogenation in the presence of palladium and charcoal of βphenyl-α-methyl-β-keto-β'-hydroxy-N-benzyl-diethylamine hydrochloride obtained from bromopropiophenone by reacting with benzyl-ethanolamine), are warmed with 10% hydrochloric acid for 6 hours on a water bath.After working up in the usual manner, the hydrochloride of the 2-phenyl-3methyl-morpholine crystallizes out from methanolic hydrochloric acid and acetone, MP = 182°C, according to US Patent 2,835,669.
Therapeutic Function
Antiobesity
