Description
trans-Nerolidol is a sesquiterpene that has been found in various plants, including
C. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties. In a disc assay,
trans-nerolidol inhibits the growth of
S. aureus,
B. subtilis,
E. coli, and
S. cerevisiae with zones of inhibition measuring 10, 9, 10, and 4 mm, respectively. It reduces viability of CaCo-2 adenocarcinoma cells with an IC
50 value of 28.7 mg/L and reduces production of reactive oxygen species (ROS).
trans-Nerolidol is insecticidal against
A. aegypti larvae with a 24-hour LC
50 value of 9 mg/L.
Occurrence
Reported to be found in cabreuva oil, oil of neroli, balsam Peru, ylang ylang and many others (Gildemeister & Hoffman, 1959).
Uses
Nerolidol (cas# 40716-66-3) is a terpene standard found in cannabis.
Preparation
By isolation from a suitable essential oil or by chemical synthesis.
Definition
ChEBI: Nerolidol is a farnesane sesquiterpenoid that is dodeca-1,6,10-triene which carries methyl groups at positions 3, 7 and 11 and a hydroxy group at position 3. It is a natural product that is present in various flowers and plants with a floral odor. Chemically, it exists in two geometric isomers, trans and cis forms. It is widely used in cosmetics (e.g. shampoos and perfumes), in non-cosmetic products (e.g. detergents and cleansers) and also as a food flavoring agent. It has a role as a flavouring agent, a cosmetic, a pheromone, a neuroprotective agent, an antifungal agent, an anti-inflammatory agent, an antihypertensive agent, an antioxidant, a volatile oil component, an insect attractant and a herbicide. It is a farnesane sesquiterpenoid, a tertiary allylic alcohol and a volatile organic compound.
