Synthesis
(1) Preparation of 3-hydroxy-1-propanesulfonic acid: 1260 kg of sodium sulfite, 1040 kg of sodium bisulfite, and 1160 kg of allyl alcohol were sequentially added to the reactor at room temperature. The pH of the reaction system was precisely adjusted to 5.5 using concentrated hydrochloric acid. infrared radiation was used as the reaction induction condition. Subsequently, 126 kg of azodiisobutyronitrile was added as a catalyst and the reaction was continued for 2.5 hours. Upon completion of the reaction, 15120 L of concentrated hydrochloric acid was added to the system and the reaction was continued at 90 °C for 2 h. The reaction was carried out at 90 °C for 2.5 h. The reaction mixture was filtered to remove the salts. The reaction mixture was filtered to remove salt impurities. The filtrate was processed by extraction and phase separation was carried out using n-butanol, resulting in 280 kg of the target product 3-hydroxy-1-propanesulfonic acid.
References
[1] Justus Liebigs Annalen der Chemie, 1954, vol. 588, p. 71,78
[2] Patent: US2806876, 1954,
[3] Journal of Organic Chemistry, 1938, vol. 3, p. 186
[4] Russian Journal of Applied Chemistry, 1998, vol. 71, # 11, p. 2047 - 2048
[5] Patent: CN105348254, 2016, A. Location in patent: Paragraph 0039; 0041
