Broad-spectrum penicillin Chemical Properties Uses production method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
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Ampicillin sodium

Broad-spectrum penicillin Chemical Properties Uses production method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
Ampicillin sodium Structure
Ampicillin sodium
  • CAS No.69-52-3
  • Chemical Name:Ampicillin sodium
  • CBNumber:CB8151850
  • Molecular Formula:C16H18N3NaO4S
  • Formula Weight:371.39
  • MOL File:69-52-3.mol
Ampicillin sodium Property
  • Melting point: :215 °C (dec.)(lit.)
  • alpha  :+246~+272°
  • storage temp.  :2-8°C
  • solubility  :H2O: 50 mg/mL, clear, very faintly yellow
  • form  :powder
  • color  :white with slight yellow cast
  • PH :pH(100g/l, 25℃):8.0~10.0
  • Water Solubility  :Freely soluble in water. Sparingly soluble in acetone
  • BRN  :4119211
  • CAS DataBase Reference :69-52-3(CAS DataBase Reference)
  • FDA UNII :JFN36L5S8K
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H317-H334
  • Precautionary statements P261-P280-P342+P311-P284-P304+P340-P280g-P342+P311a-P501a
Ampicillin sodium Price More Price(55)
  • Brand: Sigma-Aldrich
  • Product number: 171254
  • Product name : Ampicillin, Sodium Salt - CAS 69-52-3 - Calbiochem
  • Purity: Ampicillinsaltisanantibioticthatinhibitsbacterialcell-wallsynthesis.Ac
  • Packaging: 5 g
  • Price: $69.37
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 171254
  • Product name : Ampicillin, Sodium Salt - CAS 69-52-3 - Calbiochem
  • Purity: Ampicillinsaltisanantibioticthatinhibitsbacterialcell-wallsynthesis.Ac
  • Packaging: 25 g
  • Price: $239.57
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1033203
  • Product name : Ampicillin sodium
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 125mg
  • Price: $297
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 171255-M
  • Product name : Ampicillin, Sodium Salt, Sterile, Tissue Culture Grade
  • Purity: 
  • Packaging: 20ml-m
  • Price: $57.9
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 171255-M
  • Product name : Ampicillin, Sodium Salt, Sterile, Tissue Culture Grade - CAS 69-52-3 - Calbiochem
  • Purity: sterile, suitable for tissue culture
  • Packaging: 20 mL
  • Price: $62.2
  • Updated: 2021/12/16
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Ampicillin sodium Chemical Properties,Usage,Production

  • Broad-spectrum penicillin Ampicillin sodium is a broad-spectrum penicillin, its antibacterial spectrum is broader than penicillin , it has antibacterial activity on some gram-negative bacteria (such as Haemophilus influenzae, Escherichia coli, Proteus mirabilis) . Its effects on gram-positive cocci are similar to penicillin. Enzymatic hydrolysis of penicillin produced by bacteria may also make it inactive. It is clinically applicable in the treatment of respiratory infections, urinary tract infections, gastrointestinal tract infections, skin and soft tissue infections, meningitis, septicemia, endocarditis caused by sensitive bacteria. This product is a drug of choice for enterococcal infections.
    The above information is edited by the chemicalbook of Tian Ye.
  • Chemical Properties White or almost white powder or crystal. Soluble in water, slightly soluble in ethanol, insoluble in ether. Hygroscopic, when it is set at room temperature in an aqueous solution ,it gradually turns yellow,produces turbidity, decreases potency. Odorless, slightly bitter taste.
  • Uses A semi-synthetic broad-spectrum penicillin,it is mainly used for treatment of penicillin-sensitive gram-positive bacteria, Escherichia coli, Proteus, Salmonella, Shigella and other.
  • production method It is derived from the ampicillin salifying : Ampicillin is suspended in water, adjust to pH 9 with sodium hydroxide solution, dissolve and filter . The filtrate is added active carbon, and is filtered and the filtrate is dried at a low temperature, to obtain the product.
  • Category Toxic substances
  • Toxicity grading Low toxic
  • Acute toxicity Oral-rat LD50:> 5314 mg/kg; Oral-Mouse LD50:> 5314 mg/kg.
  • Flammability and hazard characteristics Combustion produces toxic sodium oxide, nitrogen oxide and sulfur oxide gases.
  • Storage Characteristics Ventilated, low-temperature ,dry storeroom.
  • Extinguishing agent Water, dry powder, foam, sand.
  • Chemical Properties White or almost white powder, hygroscopic.
  • Uses Penicillin antibacterial.
  • Uses diuretic, anti-hypertensive
  • Uses Ampicillin sodium salt is a reagent for transformed cells expressing beta-lactamase. It acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.
  • brand name Polycillin-N (Bristol-Myers Squibb).
  • General Description
    Chemical structure: ?-lactam
  • Biochem/physiol Actions Mode of Action: This is a ?-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Mode of Resistance: Administration with ?-lactamase cleaves the ?-lactam ring of Ampicillin and inactivates it. Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.
  • Contact allergens Ampicillin caused contact dermatitis in a nurse also sensitized to amoxicillin (with tolerance to oral phenoxymethylpenicillin) and in a pharmaceutical factory worker. Systemic drug reactions are common. Crossreactivity is regular with ampicillin and can occur with other penicillins.
  • Safety Profile Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: hypermotility, diarrhea, and other gastrointestinal changes. Questionable carcinogen. When heated to decomposition it emits very toxic fumes of NOx, Na2O, and SOx.
Ampicillin sodium Preparation Products And Raw materials
Raw materials
Preparation Products
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  • 4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-(2R)-aminophenylacetylamino-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)-
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  • Alppen-N
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  • Sodium [2S-[2α,5α,6β(S*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
  • Sodium ampicillin
  • AMPICILLIN SODIUM SALT, PURE 98% MIN.
  • CSL Austrapen Composition (Ampicillin sodium)
  • ampicillin sodium soluble powder
  • Ampicillin, Sodium Salt, Sterile, Tissue Culture Grade - CAS 69-52-3 - Calbiochem
  • sodium (5R,6R)-6-[[(2R)-2-amino-1-oxo-2-phenylethyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
  • (2S,5R,6R)-6-[[(2R)-2-Amino-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt
  • AMpicilllin sodiuM salt
  • CITRIC ACID 3NA SALT 2H2O REAGENT GR
  • Ampicillin sodium salt, >=98.5%
  • AMMONIUM ACETATE ULTRA PURE GRADE
  • Ampicillin sodium salt, cell culture grade
  • Ampicillin Sodium Salt, Antibiotic for Culture Media Use Only
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  • XLD AGAR
  • sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate